Production of 20-HETE and Its Role in Autoregulation of Cerebral Blood Flow

In the brain, pressure-induced myogenic constriction of cerebral arteriolar muscle contributes to autoregulation of cerebral blood flow (CBF). This study examined the role of 20-HETE in autoregulation of CBF in anesthetized rats. The expression of P-450 4A protein and mRNA was localized in isolated...

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Veröffentlicht in:	Circulation research 2000-07, Vol.87 (1), p.60-65
Hauptverfasser:	Gebremedhin, Debebe, Lange, Andrew R, Lowry, Timothy F, Taheri, M Reza, Birks, Eric K, Hudetz, Antal G, Narayanan, Jayashree, Falck, John R, Okamoto, Hirotsugu, Roman, Richard J, Nithipatikom, Kasem, Campbell, William B, Harder, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Animals Biological and medical sciences Cerebral Arteries - physiology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation Cytochrome P-450 CYP4A Cytochrome P-450 Enzyme System - genetics Fundamental and applied biological sciences. Psychology Homeostasis Hydroxyeicosatetraenoic Acids - antagonists & inhibitors Hydroxyeicosatetraenoic Acids - physiology In Vitro Techniques Microsomes - metabolism Mixed Function Oxygenases - genetics Muscle, Smooth, Vascular - metabolism Rats RNA, Messenger - analysis Sulfones - pharmacology Vasoconstriction Vertebrates: nervous system and sense organs
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