Statistical analysis on a series of glycine antagonists

Quantitative structure–activity relationships of two series of glycine antagonists, pyrido[2,3- b]pyrazines and pyrido[2,3- b]pyrazine N-oxides, was performed using PLS (Projection on Latent Variables) and traditional physico-chemical and topological descriptors. The effect of substitution on the he...

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Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 2000-03, Vol.55 (3), p.194-196
Hauptverfasser:	Tedesco, Giovanna, Feriani, Aldo, Mor, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Phenomena Chemistry, Physical Data Interpretation, Statistical Glycine Glycine - antagonists & inhibitors Glycine Agents - chemical synthesis Glycine Agents - pharmacology NMDA PLS Pyrido[2,3- b]pyrazine N-oxides Pyrido[2,3- b]pyrazines QSAR Statistical analysis Structure-Activity Relationship
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