NF-kappa B as a central mediator in the induction of TGF-beta in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasis

Immune-mediated mechanisms have been implicated in the etiology of idiopathic bone marrow fibrosis (IMF). However, the mechanism remains poorly defined. Compared with healthy controls, IMF monocytes are overactivated, with increased production of TGF-beta and IL-1. TGF-beta is central to the progres...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-08, Vol.165 (4), p.2271-2277
Hauptverfasser:	Rameshwar, P, Narayanan, R, Qian, J, Denny, T N, Colon, C, Gascon, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Biological Transport - immunology Bone Marrow - pathology Cell Adhesion - immunology Cell Line Cell Nucleus - immunology Cell Nucleus - metabolism Cell Separation Homeostasis - immunology Humans Interleukin-1 - physiology Ligases - deficiency Ligases - genetics Ligases - metabolism Macrophage Activation Mice Middle Aged Monocytes - immunology Monocytes - metabolism NF-kappa B - blood NF-kappa B - physiology Oligonucleotides, Antisense - pharmacology Primary Myelofibrosis - blood Primary Myelofibrosis - immunology Primary Myelofibrosis - pathology Rats RelA protein Transforming Growth Factor beta - biosynthesis
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