Effects of exercise and disuse on bone remodeling, bone mass, and biomechanical competence in spontaneously diabetic female rats

Diabetes is associated with low bone formation. In this study we investigate the effect of additional or reduced mechanical loading on indices of bone formation and resorption, bone mass, and biomechanical properties in spontaneously diabetic BB rats. Female diabetic (mean age 13 weeks) and age-matc...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2000-08, Vol.27 (2), p.249-256
Hauptverfasser:	Verhaeghe, J, Thomsen, J.S, van Bree, R, van Herck, E, Bouillon, R, Mosekilde, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Analysis of Variance Animals Associated diseases and complications Biological and medical sciences Biomechanical properties Blood Glucose Bone Density - physiology Bone Remodeling - physiology Calcium - blood Calcium - urine Diabetes Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Drinking Eating Endocrine pancreas. Apud cells (diseases) Endocrinopathies Exercise Female Femur - cytology Femur - physiology Fundamental and applied biological sciences. Psychology Immobilization Insulin - blood Insulin-Like Growth Factor I - metabolism Medical sciences Osteoblasts - physiology Osteocalcin - blood Parathyroid Hormone - blood Phosphates - blood Physical Conditioning, Animal - physiology Polyuria - physiopathology Rats Rats, Wistar Skeleton and joints Space life sciences Tibia - cytology Tibia - physiology Unloading Urine Vertebrates: osteoarticular system, musculoskeletal system Weight-Bearing - physiology
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