Phenotypic diversity and molecular mechanisms of airway smooth muscle proliferation in asthma

Chronic persistent asthma is characterized by poorly reversible airflow obstruction and airways inflammation and remodelling. Histopathological studies of airways removed at post mortem from patients with severe asthma reveal marked inflammatory and architectural changes associated with airway wall...

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Veröffentlicht in:	The European respiratory journal 2000-07, Vol.16 (1), p.159-177
Hauptverfasser:	Hirst, SJ, Walker, TR, Chilvers, ER
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Asthmatic Agents - pharmacology Asthma - pathology Asthma - physiopathology Biological and medical sciences Cell Division Chronic obstructive pulmonary disease, asthma Growth Substances - physiology GTP-Binding Proteins - physiology Humans Medical sciences Mitogen-Activated Protein Kinases - physiology Muscle Contraction Muscle, Smooth - pathology Muscle, Smooth - physiopathology Phenotype Phosphatidylinositol 3-Kinases - physiology Pneumology Protein Kinase C - physiology Respiratory System - pathology Respiratory System - physiopathology Signal Transduction - drug effects
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