Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction

Aminoacyl-tRNA synthetases play a key role in protein biosynthesis by catalyzing the specific aminoacylation of tRNA. The energy required for the formation of the ester bond between the amino acid carboxylate group and the tRNA acceptor stem is supplied by coupling the reaction to the hydrolysis of...

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Veröffentlicht in:	Biochemistry (Easton) 2000-07, Vol.39 (29), p.8418-8425
Hauptverfasser:	Desogus, Gianluigi, Todone, Flavia, Brick, Peter, Onesti, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Amino Acid Sequence Amino Acyl-tRNA Synthetases - genetics Catalytic Domain Crystallography, X-Ray Escherichia coli Escherichia coli - enzymology Escherichia coli - genetics Ligands Lysine - metabolism Lysine-tRNA Ligase - chemistry Lysine-tRNA Ligase - genetics Lysine-tRNA Ligase - metabolism LysU protein Models, Molecular Molecular Sequence Data Protein Conformation Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid Static Electricity
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