Molecular subclassification of kidney tumors and the discovery of new diagnostic markers

We analysed the expression profiles of 70 kidney tumors of different histological subtypes to determine if these subgroups can be distinguished by their gene expression profiles, and to gain insights into the molecular mechanisms underlying each subtype. In all, 39 clear cell renal cell carcinomas (...

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Veröffentlicht in:	Oncogene 2003-10, Vol.22 (43), p.6810-6818
Hauptverfasser:	TAKAHASHI, Masayuki, YANG, Ximing J, NICOL, David, VOGELZANG, Nicholas J, FURGE, Kyle A, KANAYAMA, Hiroomi, KAGAWA, Susumu, BIN TEAN TEH, SUGIMURA, Jun, BACKDAHL, Jesper, TRETIAKOVA, Maria, QIAN, Chao-Nan, GRAY, Steven G, KNAPP, Robert, ANEMA, John, KAHNOSKI, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor Cancer Carbonic anhydrase II Carcinoma, Renal Cell - genetics Carcinoma, Transitional Cell - genetics Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosomes Clear cell-type renal cell carcinoma Cluster Analysis DNA microarrays DNA, Complementary - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Neoplastic Glutathione transferase Glutathione Transferase - metabolism Hospitals Humans Immunohistochemistry Kidney - metabolism Kidney cancer Kidney Neoplasms - genetics Kidneys Medical prognosis Medical sciences Medicine Metastases methylacyl racemase Molecular and cellular biology Molecular modelling Multigene Family Mutation Nephrology. Urinary tract diseases Oligonucleotide Array Sequence Analysis Pelvis renal cell carcinoma RNA - metabolism Transitional cell carcinoma Tumors Tumors of the urinary system Urology Wilms Tumor - genetics
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