Attenuated nef DNA vaccine construct induces cellular immune response: role in HIV-1 multiprotein vaccine

HIV-1 positive patients generate Nef-specific CTL response, indicating that Nef is a potent immunogen. However, Nef is also known to down regulate the expression of CD4 and MHC-I molecules, thereby protecting virally infected target cells. We compared the immunogenicity of non-functional nef vaccine...

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Veröffentlicht in:	Immunology letters 2003-10, Vol.89 (2), p.207-214
Hauptverfasser:	Majumder, Biswanath, Gray, Benjamin, McBurney, Sean, Schaefer, Todd M., Dentchev, Tzvete, Mahalingam, Sundarasamy, Reinhart, Todd A., Ayyavoo, Velpandi
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - immunology AIDS Vaccines - pharmacology Animals CTL Epitope Mapping Epitopes - immunology Gene Products, nef - genetics Gene Products, nef - immunology HIV Infections - prevention & control HIV-1 Nef Human immunodeficiency virus 1 Humans Immune System - drug effects Immune System - immunology Immune System - metabolism Immunologic Memory - immunology Interferon-gamma - drug effects Mice nef Gene Products, Human Immunodeficiency Virus Nef protein T cell immunity Vaccines, DNA - immunology Vaccines, DNA - pharmacology
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