Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease
Background Although reduced intracellular levels of magnesium have been described in patients with acute myocardial infarction, its significance as a regulator of thrombosis remains unknown. Methods and Results To determine whether reduced intracellular levels of magnesium enhance platelet-dependent...
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| Veröffentlicht in: | The American heart journal 2000-08, Vol.140 (2), p.212-218 |
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| container_title | The American heart journal |
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| creator | Shechter, Michael Merz, C.Noel Bairey Rude, Robert K. Paul Labrador, Maura J. Meisel, Simcha R. Shah, Prediman K. Kaul, Sanjay |
| description | Background Although reduced intracellular levels of magnesium have been described in patients with acute myocardial infarction, its significance as a regulator of thrombosis remains unknown. Methods and Results To determine whether reduced intracellular levels of magnesium enhance platelet-dependent thrombosis, we evaluated 42 patients with coronary artery disease (CAD) by exposing porcine aortic media to their flowing unanticoagulated venous blood for 5 minutes by using an ex vivo perfusion (Badimon) chamber. Baseline analysis demonstrated significant associations between intracellular levels of magnesium, platelet-dependent thrombosis (P =.02), and platelet P-selectin (CD62P) expression (P |
| doi_str_mv | 10.1067/mhj.2000.107553 |
| format | Article |
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Methods and Results To determine whether reduced intracellular levels of magnesium enhance platelet-dependent thrombosis, we evaluated 42 patients with coronary artery disease (CAD) by exposing porcine aortic media to their flowing unanticoagulated venous blood for 5 minutes by using an ex vivo perfusion (Badimon) chamber. Baseline analysis demonstrated significant associations between intracellular levels of magnesium, platelet-dependent thrombosis (P =.02), and platelet P-selectin (CD62P) expression (P <.05). Patients were divided into 2 groups: below (n = 22) and above (n = 20) the median intracellular levels of magnesium (1.12 μg/mg protein). There were no significant differences in age, body mass index, serum lipids, fibrinogen, platelet count, or serum magnesium levels between the two groups. Platelet-dependent thrombosis was significantly higher in patients with intracellular levels of magnesium below compared with above median (150 ± 128 vs 45 ± 28 μm2/mm, P <.004). Neither platelet aggregation nor CD62P expression was significantly different between the two groups. Conclusions Platelet-dependent thrombosis was significantly increased in patients with stable CAD with low intracellular levels of magnesium, suggesting a potential role for magnesium supplementation in CAD. (Am Heart J 2000;140:212-8.)</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1067/mhj.2000.107553</identifier><identifier>PMID: 10925332</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Animals ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary Disease - blood ; Coronary heart disease ; Coronary Thrombosis - blood ; Female ; Heart ; Humans ; Intracellular Fluid - metabolism ; Magnesium - blood ; Magnesium Deficiency - blood ; Male ; Medical sciences ; Middle Aged ; P-Selectin - blood ; Platelet Aggregation - physiology ; Risk Factors ; Swine ; Thrombosis - blood</subject><ispartof>The American heart journal, 2000-08, Vol.140 (2), p.212-218</ispartof><rights>2000 Mosby, Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-2bc4d3ef5ab0224575cc91ca6ced212bba997c0485966e96f8eaa090d2cb15143</citedby><cites>FETCH-LOGICAL-c372t-2bc4d3ef5ab0224575cc91ca6ced212bba997c0485966e96f8eaa090d2cb15143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002870300452865$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1487043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10925332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shechter, Michael</creatorcontrib><creatorcontrib>Merz, C.Noel Bairey</creatorcontrib><creatorcontrib>Rude, Robert K.</creatorcontrib><creatorcontrib>Paul Labrador, Maura J.</creatorcontrib><creatorcontrib>Meisel, Simcha R.</creatorcontrib><creatorcontrib>Shah, Prediman K.</creatorcontrib><creatorcontrib>Kaul, Sanjay</creatorcontrib><title>Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Background Although reduced intracellular levels of magnesium have been described in patients with acute myocardial infarction, its significance as a regulator of thrombosis remains unknown. Methods and Results To determine whether reduced intracellular levels of magnesium enhance platelet-dependent thrombosis, we evaluated 42 patients with coronary artery disease (CAD) by exposing porcine aortic media to their flowing unanticoagulated venous blood for 5 minutes by using an ex vivo perfusion (Badimon) chamber. Baseline analysis demonstrated significant associations between intracellular levels of magnesium, platelet-dependent thrombosis (P =.02), and platelet P-selectin (CD62P) expression (P <.05). Patients were divided into 2 groups: below (n = 22) and above (n = 20) the median intracellular levels of magnesium (1.12 μg/mg protein). There were no significant differences in age, body mass index, serum lipids, fibrinogen, platelet count, or serum magnesium levels between the two groups. Platelet-dependent thrombosis was significantly higher in patients with intracellular levels of magnesium below compared with above median (150 ± 128 vs 45 ± 28 μm2/mm, P <.004). Neither platelet aggregation nor CD62P expression was significantly different between the two groups. Conclusions Platelet-dependent thrombosis was significantly increased in patients with stable CAD with low intracellular levels of magnesium, suggesting a potential role for magnesium supplementation in CAD. (Am Heart J 2000;140:212-8.)</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - blood</subject><subject>Coronary heart disease</subject><subject>Coronary Thrombosis - blood</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Intracellular Fluid - metabolism</subject><subject>Magnesium - blood</subject><subject>Magnesium Deficiency - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>P-Selectin - blood</subject><subject>Platelet Aggregation - physiology</subject><subject>Risk Factors</subject><subject>Swine</subject><subject>Thrombosis - blood</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc-P1SAQx4nRuM_VszfDwXjrLtACj6PZ-Ct5iRc9kymd-tjQ0gW6G_97afoSvXgiw3z4ZuYDIW85u-FM6dvpfH8jGNsqLWX7jBw4M7pRuuuek0NtiOaoWXtFXuV8X0sljuoluaqQkG0rDuThFJ-on0sChyGsARKd4NeM2a8TDfiIIdMlxSkWpEuAggFLM-CC84BzoeVce33MPtcQukDx9TbTJ1_O1MUUZ0i_KaSC9Rh8Rsj4mrwYIWR8czmvyc_Pn37cfW1O3798u_t4alyrRWlE77qhxVFCz4TopJbOGe5AORwEF30PxmjHuqM0SqFR4xEBmGGDcD2XvGuvyYc9t47_sGIudvJ5WxJmjGu2mgslW2EqeLuDLsWcE452SX6qg1vO7GbZVst2s2x3y_XFu0v02k84_MPvWivw_gJAdhDGBLPz-S_X1U_pthyzY9UyPnpMNrsqsG7oE7pih-j_O8MfSfmbWA</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>Shechter, Michael</creator><creator>Merz, C.Noel Bairey</creator><creator>Rude, Robert K.</creator><creator>Paul Labrador, Maura J.</creator><creator>Meisel, Simcha R.</creator><creator>Shah, Prediman K.</creator><creator>Kaul, Sanjay</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000801</creationdate><title>Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease</title><author>Shechter, Michael ; Merz, C.Noel Bairey ; Rude, Robert K. ; Paul Labrador, Maura J. ; Meisel, Simcha R. ; Shah, Prediman K. ; Kaul, Sanjay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-2bc4d3ef5ab0224575cc91ca6ced212bba997c0485966e96f8eaa090d2cb15143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - blood</topic><topic>Coronary heart disease</topic><topic>Coronary Thrombosis - blood</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Intracellular Fluid - metabolism</topic><topic>Magnesium - blood</topic><topic>Magnesium Deficiency - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>P-Selectin - blood</topic><topic>Platelet Aggregation - physiology</topic><topic>Risk Factors</topic><topic>Swine</topic><topic>Thrombosis - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shechter, Michael</creatorcontrib><creatorcontrib>Merz, C.Noel Bairey</creatorcontrib><creatorcontrib>Rude, Robert K.</creatorcontrib><creatorcontrib>Paul Labrador, Maura J.</creatorcontrib><creatorcontrib>Meisel, Simcha R.</creatorcontrib><creatorcontrib>Shah, Prediman K.</creatorcontrib><creatorcontrib>Kaul, Sanjay</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shechter, Michael</au><au>Merz, C.Noel Bairey</au><au>Rude, Robert K.</au><au>Paul Labrador, Maura J.</au><au>Meisel, Simcha R.</au><au>Shah, Prediman K.</au><au>Kaul, Sanjay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>140</volume><issue>2</issue><spage>212</spage><epage>218</epage><pages>212-218</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Background Although reduced intracellular levels of magnesium have been described in patients with acute myocardial infarction, its significance as a regulator of thrombosis remains unknown. Methods and Results To determine whether reduced intracellular levels of magnesium enhance platelet-dependent thrombosis, we evaluated 42 patients with coronary artery disease (CAD) by exposing porcine aortic media to their flowing unanticoagulated venous blood for 5 minutes by using an ex vivo perfusion (Badimon) chamber. Baseline analysis demonstrated significant associations between intracellular levels of magnesium, platelet-dependent thrombosis (P =.02), and platelet P-selectin (CD62P) expression (P <.05). Patients were divided into 2 groups: below (n = 22) and above (n = 20) the median intracellular levels of magnesium (1.12 μg/mg protein). There were no significant differences in age, body mass index, serum lipids, fibrinogen, platelet count, or serum magnesium levels between the two groups. Platelet-dependent thrombosis was significantly higher in patients with intracellular levels of magnesium below compared with above median (150 ± 128 vs 45 ± 28 μm2/mm, P <.004). Neither platelet aggregation nor CD62P expression was significantly different between the two groups. Conclusions Platelet-dependent thrombosis was significantly increased in patients with stable CAD with low intracellular levels of magnesium, suggesting a potential role for magnesium supplementation in CAD. (Am Heart J 2000;140:212-8.)</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10925332</pmid><doi>10.1067/mhj.2000.107553</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Animals Biological and medical sciences Cardiology. Vascular system Coronary Disease - blood Coronary heart disease Coronary Thrombosis - blood Female Heart Humans Intracellular Fluid - metabolism Magnesium - blood Magnesium Deficiency - blood Male Medical sciences Middle Aged P-Selectin - blood Platelet Aggregation - physiology Risk Factors Swine Thrombosis - blood |
| title | Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease |
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