Effects of High-Molecular-Weight Cryoprotectants on Platelets and the Coagulation System

The objective of this study is to examine the effects of the most widely used high-molecular-weight cryoprotectants on the coagulation system. Dextran, hydryoxyethyl starch (HES), polyvinyl pyrrolidone (PVP), polyethylene glycol (PEG), and albumin were added at different concentrations in the range...

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Veröffentlicht in:	Cryobiology 2000-06, Vol.40 (4), p.283-293
Hauptverfasser:	Bakaltcheva, Irina, Ganong, Jason P., Holtz, Bonnie L., Peat, Raquel A., Reid, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - pharmacology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Coagulation - drug effects Blood Platelets - drug effects Blood Preservation Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis clot retraction coagulation Cryopreservation cryoprotectants Cryoprotective Agents - chemistry Cryoprotective Agents - pharmacology dextran Dextrans - pharmacology Factor V - metabolism Factor VIII - metabolism freeze-drying Humans Hydroxyethyl Starch Derivatives - pharmacology hydryoxyethyl starch In Vitro Techniques Medical sciences Molecular Weight Partial Thromboplastin Time PEG Platelet Aggregation - drug effects polyethylene glycol Polyethylene Glycols - pharmacology polyvinylpyrrolidone Povidone - pharmacology Prothrombin Time PVP thrombin Thrombin Time thromboplastin Transfusions. Complications. Transfusion reactions. Cell and gene therapy vitrification
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