Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome
Objectives. Granulocyte-macrophage colony stimulating factor (GM-CSF) is a key regulator cytokine that modulates the proliferation and maturation of polymorphonuclear and mononuclear progenitors. This study was designed to investigate and clarify the role of GM-CSF in 52 critically ill patients with...
Gespeichert in:
| Veröffentlicht in: | The Journal of infection 2003-11, Vol.47 (4), p.296-299 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 299 |
|---|---|
| container_issue | 4 |
| container_start_page | 296 |
| container_title | The Journal of infection |
| container_volume | 47 |
| creator | Torre, Donato Tambini, Roberto Manfredi, Mariangela Mangani, Valerio Livi, Paola Maldifassi, Viviana Chiaranda, Maurizio Campi, Paolo Speranza, Filippo |
| description | Objectives. Granulocyte-macrophage colony stimulating factor (GM-CSF) is a key regulator cytokine that modulates the proliferation and maturation of polymorphonuclear and mononuclear progenitors. This study was designed to investigate and clarify the role of GM-CSF in 52 critically ill patients with systemic inflammatory response syndrome (SIRS).
Methods. Serum levels of GM-CSF were detected by an immunoenzyme assay.
Results. Our results clearly show that the serum concentrations of GM-CSF were significantly elevated in patients with infectious and noninfectious SIRS (33.2±45.7
pg/ml, controls: 17.2±9.8
pg/ml;
p=0.0303). In addition, GM-CSF levels significantly decreased in patients with SIRS, particularly in patients with infectious SIRS, 5 and 7 days later. There was a clear tendency toward higher levels of GM-CSF in patients with poor, as compared with those having a good outcome of the disease.
Conclusion. These results show that GM-CSF may play an important role in patients with infectious and noninfectious SIRS, and that GM-CSF levels progressively and significantly decrease in patients with infectious SIRS. |
| doi_str_mv | 10.1016/S0163-4453(03)00065-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71263846</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0163445303000653</els_id><sourcerecordid>71263846</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-efd37fe7fcd217c382719ef0e5ffe8ecd5bd08d9ae218b010a3acd0076eab1c23</originalsourceid><addsrcrecordid>eNqFkc2OFCEURonROD2jj6Bho9FFKT9FUbUypuOoySQu1DWh4dKNoYoSqDG19sWl7dZZTkIgufd8cMNB6Bklbyih3duvdeNN2wr-ivDXhJBONPwB2lDBWcNkyx6izX_kAl3m_KNCAx-6x-iCtkJ0UvAN-r31ySxBFz_tcYBbCBlHh_dJT0uIZi2AR21SnA96D9jEEKe1ycWP_zJOmxIT9hOeawGmkvEvXw64HADnNRcYvaldF_Q46kquOEGe45SP7cmmOMIT9MjpkOHp-bxC368_fNt-am6-fPy8fX_TmJax0oCzXDqQzlhGpeE9k3QAR0A4Bz0YK3aW9HbQwGi_I5Roro0lRHagd9QwfoVenu6dU_y5QC5q9NlACHqCuGQlKet433b3gozIfpCCVlCcwPpDOSdwak5-1GlVlKijJvVXkzo6UKSuoybFa-75-YFlN4K9S529VODFGdDZ6OCqDuPzHScYJYL1lXt34qo3uPWQVDZVggHrE5iibPT3jPIHg4mzzg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20789751</pqid></control><display><type>article</type><title>Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Torre, Donato ; Tambini, Roberto ; Manfredi, Mariangela ; Mangani, Valerio ; Livi, Paola ; Maldifassi, Viviana ; Chiaranda, Maurizio ; Campi, Paolo ; Speranza, Filippo</creator><creatorcontrib>Torre, Donato ; Tambini, Roberto ; Manfredi, Mariangela ; Mangani, Valerio ; Livi, Paola ; Maldifassi, Viviana ; Chiaranda, Maurizio ; Campi, Paolo ; Speranza, Filippo</creatorcontrib><description>Objectives. Granulocyte-macrophage colony stimulating factor (GM-CSF) is a key regulator cytokine that modulates the proliferation and maturation of polymorphonuclear and mononuclear progenitors. This study was designed to investigate and clarify the role of GM-CSF in 52 critically ill patients with systemic inflammatory response syndrome (SIRS).
Methods. Serum levels of GM-CSF were detected by an immunoenzyme assay.
Results. Our results clearly show that the serum concentrations of GM-CSF were significantly elevated in patients with infectious and noninfectious SIRS (33.2±45.7
pg/ml, controls: 17.2±9.8
pg/ml;
p=0.0303). In addition, GM-CSF levels significantly decreased in patients with SIRS, particularly in patients with infectious SIRS, 5 and 7 days later. There was a clear tendency toward higher levels of GM-CSF in patients with poor, as compared with those having a good outcome of the disease.
Conclusion. These results show that GM-CSF may play an important role in patients with infectious and noninfectious SIRS, and that GM-CSF levels progressively and significantly decrease in patients with infectious SIRS.</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/S0163-4453(03)00065-3</identifier><identifier>PMID: 14556753</identifier><identifier>CODEN: JINFD2</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Analysis of Variance ; Biological and medical sciences ; Colony stimulating factor ; Enzyme-Linked Immunosorbent Assay ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects ; Granulocyte-macrophage ; Granulocyte-Macrophage Colony-Stimulating Factor - blood ; Humans ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Statistics, Nonparametric ; Systemic inflammatory response syndrome ; Systemic Inflammatory Response Syndrome - blood ; Virology</subject><ispartof>The Journal of infection, 2003-11, Vol.47 (4), p.296-299</ispartof><rights>2003 The British Infection Society</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-efd37fe7fcd217c382719ef0e5ffe8ecd5bd08d9ae218b010a3acd0076eab1c23</citedby><cites>FETCH-LOGICAL-c422t-efd37fe7fcd217c382719ef0e5ffe8ecd5bd08d9ae218b010a3acd0076eab1c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0163445303000653$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15210528$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14556753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torre, Donato</creatorcontrib><creatorcontrib>Tambini, Roberto</creatorcontrib><creatorcontrib>Manfredi, Mariangela</creatorcontrib><creatorcontrib>Mangani, Valerio</creatorcontrib><creatorcontrib>Livi, Paola</creatorcontrib><creatorcontrib>Maldifassi, Viviana</creatorcontrib><creatorcontrib>Chiaranda, Maurizio</creatorcontrib><creatorcontrib>Campi, Paolo</creatorcontrib><creatorcontrib>Speranza, Filippo</creatorcontrib><title>Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome</title><title>The Journal of infection</title><addtitle>J Infect</addtitle><description>Objectives. Granulocyte-macrophage colony stimulating factor (GM-CSF) is a key regulator cytokine that modulates the proliferation and maturation of polymorphonuclear and mononuclear progenitors. This study was designed to investigate and clarify the role of GM-CSF in 52 critically ill patients with systemic inflammatory response syndrome (SIRS).
Methods. Serum levels of GM-CSF were detected by an immunoenzyme assay.
Results. Our results clearly show that the serum concentrations of GM-CSF were significantly elevated in patients with infectious and noninfectious SIRS (33.2±45.7
pg/ml, controls: 17.2±9.8
pg/ml;
p=0.0303). In addition, GM-CSF levels significantly decreased in patients with SIRS, particularly in patients with infectious SIRS, 5 and 7 days later. There was a clear tendency toward higher levels of GM-CSF in patients with poor, as compared with those having a good outcome of the disease.
Conclusion. These results show that GM-CSF may play an important role in patients with infectious and noninfectious SIRS, and that GM-CSF levels progressively and significantly decrease in patients with infectious SIRS.</description><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Colony stimulating factor</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Granulocyte-macrophage</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Statistics, Nonparametric</subject><subject>Systemic inflammatory response syndrome</subject><subject>Systemic Inflammatory Response Syndrome - blood</subject><subject>Virology</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEURonROD2jj6Bho9FFKT9FUbUypuOoySQu1DWh4dKNoYoSqDG19sWl7dZZTkIgufd8cMNB6Bklbyih3duvdeNN2wr-ivDXhJBONPwB2lDBWcNkyx6izX_kAl3m_KNCAx-6x-iCtkJ0UvAN-r31ySxBFz_tcYBbCBlHh_dJT0uIZi2AR21SnA96D9jEEKe1ycWP_zJOmxIT9hOeawGmkvEvXw64HADnNRcYvaldF_Q46kquOEGe45SP7cmmOMIT9MjpkOHp-bxC368_fNt-am6-fPy8fX_TmJax0oCzXDqQzlhGpeE9k3QAR0A4Bz0YK3aW9HbQwGi_I5Roro0lRHagd9QwfoVenu6dU_y5QC5q9NlACHqCuGQlKet433b3gozIfpCCVlCcwPpDOSdwak5-1GlVlKijJvVXkzo6UKSuoybFa-75-YFlN4K9S529VODFGdDZ6OCqDuPzHScYJYL1lXt34qo3uPWQVDZVggHrE5iibPT3jPIHg4mzzg</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Torre, Donato</creator><creator>Tambini, Roberto</creator><creator>Manfredi, Mariangela</creator><creator>Mangani, Valerio</creator><creator>Livi, Paola</creator><creator>Maldifassi, Viviana</creator><creator>Chiaranda, Maurizio</creator><creator>Campi, Paolo</creator><creator>Speranza, Filippo</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome</title><author>Torre, Donato ; Tambini, Roberto ; Manfredi, Mariangela ; Mangani, Valerio ; Livi, Paola ; Maldifassi, Viviana ; Chiaranda, Maurizio ; Campi, Paolo ; Speranza, Filippo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-efd37fe7fcd217c382719ef0e5ffe8ecd5bd08d9ae218b010a3acd0076eab1c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Colony stimulating factor</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Granulocyte-macrophage</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Statistics, Nonparametric</topic><topic>Systemic inflammatory response syndrome</topic><topic>Systemic Inflammatory Response Syndrome - blood</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torre, Donato</creatorcontrib><creatorcontrib>Tambini, Roberto</creatorcontrib><creatorcontrib>Manfredi, Mariangela</creatorcontrib><creatorcontrib>Mangani, Valerio</creatorcontrib><creatorcontrib>Livi, Paola</creatorcontrib><creatorcontrib>Maldifassi, Viviana</creatorcontrib><creatorcontrib>Chiaranda, Maurizio</creatorcontrib><creatorcontrib>Campi, Paolo</creatorcontrib><creatorcontrib>Speranza, Filippo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torre, Donato</au><au>Tambini, Roberto</au><au>Manfredi, Mariangela</au><au>Mangani, Valerio</au><au>Livi, Paola</au><au>Maldifassi, Viviana</au><au>Chiaranda, Maurizio</au><au>Campi, Paolo</au><au>Speranza, Filippo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome</atitle><jtitle>The Journal of infection</jtitle><addtitle>J Infect</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>47</volume><issue>4</issue><spage>296</spage><epage>299</epage><pages>296-299</pages><issn>0163-4453</issn><eissn>1532-2742</eissn><coden>JINFD2</coden><abstract>Objectives. Granulocyte-macrophage colony stimulating factor (GM-CSF) is a key regulator cytokine that modulates the proliferation and maturation of polymorphonuclear and mononuclear progenitors. This study was designed to investigate and clarify the role of GM-CSF in 52 critically ill patients with systemic inflammatory response syndrome (SIRS).
Methods. Serum levels of GM-CSF were detected by an immunoenzyme assay.
Results. Our results clearly show that the serum concentrations of GM-CSF were significantly elevated in patients with infectious and noninfectious SIRS (33.2±45.7
pg/ml, controls: 17.2±9.8
pg/ml;
p=0.0303). In addition, GM-CSF levels significantly decreased in patients with SIRS, particularly in patients with infectious SIRS, 5 and 7 days later. There was a clear tendency toward higher levels of GM-CSF in patients with poor, as compared with those having a good outcome of the disease.
Conclusion. These results show that GM-CSF may play an important role in patients with infectious and noninfectious SIRS, and that GM-CSF levels progressively and significantly decrease in patients with infectious SIRS.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>14556753</pmid><doi>10.1016/S0163-4453(03)00065-3</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4453 |
| ispartof | The Journal of infection, 2003-11, Vol.47 (4), p.296-299 |
| issn | 0163-4453 1532-2742 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71263846 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis of Variance Biological and medical sciences Colony stimulating factor Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology General aspects Granulocyte-macrophage Granulocyte-Macrophage Colony-Stimulating Factor - blood Humans Male Medical sciences Microbiology Middle Aged Predictive Value of Tests Prospective Studies Statistics, Nonparametric Systemic inflammatory response syndrome Systemic Inflammatory Response Syndrome - blood Virology |
| title | Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T00%3A03%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circulating%20levels%20of%20granulocyte%20macrophage%20colony-stimulating%20factor%20in%20patients%20with%20the%20systemic%20inflammatory%20response%20syndrome&rft.jtitle=The%20Journal%20of%20infection&rft.au=Torre,%20Donato&rft.date=2003-11-01&rft.volume=47&rft.issue=4&rft.spage=296&rft.epage=299&rft.pages=296-299&rft.issn=0163-4453&rft.eissn=1532-2742&rft.coden=JINFD2&rft_id=info:doi/10.1016/S0163-4453(03)00065-3&rft_dat=%3Cproquest_cross%3E71263846%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20789751&rft_id=info:pmid/14556753&rft_els_id=S0163445303000653&rfr_iscdi=true |