Phosphorylation of Elk-1 by MEK/ERK Pathway is Necessary for c-fos Gene Activation During Cardiac Myocyte Hypertrophy

Cardiac hypertrophy is associated with specific alterations in myocardial gene expression; however, the exact mechanisms responsible for altered gene expression are poorly defined. The goal of this study was to investigate whether signaling kinases that are activated during cardiac hypertrophy direc...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2000-08, Vol.32 (8), p.1447-1457
Hauptverfasser:	Babu, Gopal J, Lalli, Jane M, Sussman, Mark A, Sadoshima, Jun-ichi, Periasamy, Muthu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - pharmacology Animals Animals, Newborn Blotting, Western c-fos Cardiac hypertrophy Cardiomegaly - pathology Cell Nucleus - metabolism Cells, Cultured Cytosol - metabolism DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel Elk-1 Enzyme Inhibitors - pharmacology ERK ets-Domain Protein Elk-1 Flavonoids - pharmacology Genes, Reporter Imidazoles - pharmacology MAP Kinase Kinase 1 MEK Microscopy, Confocal Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism Myocardium - cytology Myocardium - metabolism Nuclear Proteins - metabolism Phenylephrine Phenylephrine - pharmacology Phosphorylation Plasmids - metabolism Promoter Regions, Genetic Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-fos - genetics Pyridines - pharmacology Rats Rats, Sprague-Dawley Serum Response Factor SRE Time Factors Transcription Factors Transfection
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