Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression

Although the beneficial effect of cimetidine on survival in cancer has been clinically demonstrated in colorectal cancer patients, the mode of action of cimetidine has not been elucidated. In this report, we have demonstrated for the first time that cimetidine can block the adhesion of a colorectal...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-07, Vol.60 (14), p.3978-3984
Hauptverfasser:	KOBAYASHI, K.-I, MATSUMOTO, S, MORISHIMA, T, KAWABE, T, OKAMOTO, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Adhesion - drug effects Cell Nucleus - metabolism Chemotherapy Cimetidine - pharmacology Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Dose-Response Relationship, Drug Down-Regulation E-Selectin - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay Famotidine - pharmacology Histamine H2 Antagonists - pharmacology Humans Interleukin-1 - metabolism Liver Neoplasms - prevention & control Liver Neoplasms - secondary Medical sciences Mice Mice, Nude Microscopy, Confocal Neoplasm Transplantation NF-kappa B - metabolism Oligosaccharides - metabolism Pharmacology. Drug treatments Ranitidine - pharmacology RNA, Messenger - metabolism Transcriptional Activation Tumor Cells, Cultured Umbilical Veins - drug effects Umbilical Veins - metabolism
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