Interleukin-6 Negatively Regulates the Expression of Pregnane X Receptor and Constitutively Activated Receptor in Primary Human Hepatocytes

The marked impairment of hepatic drug metabolism during inflammation and infections has been known for many years and shown to result from down-regulation of cytochrome P450s (CYP) by cytokines. However, the mechanism of this repression is unknown. Using primary cultures of human hepatocytes, we sho...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-08, Vol.274 (3), p.707-713
Hauptverfasser:	Pascussi, Jean-Marc, Gerbal-Chaloin, Sabine, Pichard-Garcia, Lydiane, Daujat, Martine, Fabre, Jean-Michel, Maurel, Patrick, Vilarem, Marie-José
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Cytochrome P-450 Enzyme System - metabolism Down-Regulation Humans Interleukin-6 - metabolism Interleukin-6 - pharmacology Liver - metabolism Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Steroid - metabolism Signal Transduction - drug effects Trans-Activators - metabolism Transcription Factors
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