Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity
Some 1-(4-arylthiazol-2-yl)-3,5-diaryl-2-pyrazoline derivatives were synthesized by reacting 1-thiocarbamoyl-3,5-diaryl-2-pyrazoline derivatives with phenacetylbromide in ethanol. The structural elucidation of the compounds were performed by IR, 1H-NMR and Mass spectral data and elemental analyses....
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| Veröffentlicht in: | European journal of medicinal chemistry 2000-06, Vol.35 (6), p.635-641 |
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| container_end_page | 641 |
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| container_issue | 6 |
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| container_title | European journal of medicinal chemistry |
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| creator | Turan-Zitouni, Gülhan Chevallet, Pierre Kiliç, Fatma S Erol, Kevser |
| description | Some 1-(4-arylthiazol-2-yl)-3,5-diaryl-2-pyrazoline derivatives were synthesized by reacting 1-thiocarbamoyl-3,5-diaryl-2-pyrazoline derivatives with phenacetylbromide in ethanol. The structural elucidation of the compounds were performed by IR,
1H-NMR and Mass spectral data and elemental analyses. The hypotensive activities of 13 compounds were evaluated by using the tail-cuff method. All examined compounds showed appreciable hypotensive activities. Clonidine was used as reference substance in the pharmacological evaluation. |
| doi_str_mv | 10.1016/S0223-5234(00)00152-5 |
| format | Article |
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The structural elucidation of the compounds were performed by IR,
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| fulltext | fulltext |
| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2000-06, Vol.35 (6), p.635-641 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antihypertensive agents Antihypertensive Agents - chemical synthesis Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology Biological and medical sciences Cardiovascular system chalcone Clonidine - pharmacology Drug Evaluation, Preclinical - methods Female hypotensive activity Magnetic Resonance Spectroscopy Male Mass Spectrometry Medical sciences Molecular Structure Pharmacology. Drug treatments Pyrazoles - chemistry Pyrazoles - pharmacology pyrazoline Rats Structure-Activity Relationship thiazol Thiazoles - chemistry Thiazoles - pharmacology thiazolyl-pyrazoline |
| title | Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity |
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