Derivation of Diabetes-Resistant Congenic Lines from the Nonobese Diabetic Mouse

Autoimmune diabetes is a polygenic disease process in man and rodents. To identify and characterize genes involved in the pathogenesis of diabetes in nonobese diabetic (NOD) mice, we initiated a repetitive backcross of diabetes-resistant C57L/J mice onto the NOD strain. This breeding scheme was base...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2000-08, Vol.96 (2), p.119-130
1. Verfasser:	McDuffie, Marcia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Biological and medical sciences chromosome mapping crosses Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - pathology diabetes mellitus, insulin-dependent (genetics) Diabetes. Impaired glucose tolerance disease susceptibility Disease Susceptibility - immunology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female genetic Immunity, Innate - genetics Immunity, Innate - immunology Male Medical sciences Mice mice, inbred (NOD, C57L) Mice, Inbred NOD - genetics Mice, Inbred Strains Phenotype T-Lymphocytes - immunology
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