A direct photo-activated affinity modification of tetracycline transcription repressor protein TetR(D) with tetracycline

Results of a first successful application of a direct photo-induced affinity modification of Tet repressor (TetR(D)) protein with tetracycline within a complex of known three-dimensional structure are described. The conditions of the modification have provided suitable yields of the modified complex...

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Veröffentlicht in:	FEBS letters 2000-07, Vol.477 (3), p.263-267
Hauptverfasser:	Beliakova, Maria M., Anokhina, Maria M., Spiridonova, Vera A., Dobrov, Eugeny N., Egorov, Tsezi A., Wittmann-Liebold, Brigitte, Orth, Peter, Saenger, Wolfram, Kopylov, Alexei M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding site Molecular Sequence Data Photo-activated affinity modification Photoaffinity Labels Protein sequencing Repressor Proteins - chemistry Tetracycline Tetracycline - chemistry Transcription repressor protein TetR(D) X-Ray Diffraction
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