Pax4 Represses Pancreatic Glucagon Gene Expression

The paired box and homeodomain containing transcription factors Pax4 and Pax6 are known to be essential for development of the pancreatic endocrine cells. In this report we demonstrate that stable expression of Pax4 in a rat glucagon-producing cell line inhibits the endogenously expressed glucagon g...

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Veröffentlicht in:	Molecular cell biology research communications 2000-04, Vol.3 (4), p.249-254
Hauptverfasser:	Petersen, Helle V., Jørgensen, Mette C., Andersen, Frank G., Jensen, Jan, F-Nielsen, Tove, Jørgensen, Ragna, Madsen, Ole D., Serup, Palle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line DNA-Binding Proteins - physiology Eye Proteins Fluorescent Antibody Technique Gene Expression Regulation glucagon Glucagon - genetics Glucagon - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism In Situ Hybridization insulin Insulin - genetics Islets of Langerhans - metabolism Mice Paired Box Transcription Factors Pax4 Pax6 PAX6 Transcription Factor Pdx1 Promoter Regions, Genetic - genetics Rats repression Repressor Proteins - genetics Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transfection Tumor Cells, Cultured
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