Safety, immunogenicity and efficacy in healthy infants of G1 and G2 human reassortant rotavirus vaccine in a new stabilizer/buffer liquid formulation

BACKGROUND.A refrigerator-stable rotavirus (RV) vaccine that withstands gastric acid is anticipated to permit more widespread use of RV vaccine. OBJECTIVE.We investigated for the first time in infants an oral, liquid formulation of G1 and G2 human bovine reassortant rotavirus vaccine (HRRV) with a n...

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Veröffentlicht in:	The Pediatric infectious disease journal 2003-10, Vol.22 (10), p.914-920
Hauptverfasser:	CLARK, H FRED, BURKE, CARL J, VOLKIN, DAVID B, OFFIT, PAUL, WARD, RICHARD L, BRESEE, JOSEPH S, DENNEHY, PENELOPE, GOOCH, W MANFRED, MALACAMAN, EDGARDO, MATSON, DAVID, WALTER, EMMANUEL, WATSON, BARBARA, KRAH, DAVID L, DALLAS, MICHAEL J, SCHÖDEL, FLORIAN, KAPLAN, KAREN M, HEATON, PENNY
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemistry, Pharmaceutical Confidence Intervals Double-Blind Method Feces - virology Female Follow-Up Studies Human viral diseases Humans Immunity - physiology Infant Infectious diseases Male Medical sciences Reference Values Rotavirus - immunology Rotavirus Infections - prevention & control Rotavirus Vaccines - administration & dosage Rotavirus Vaccines - immunology Safety Sensitivity and Specificity Vaccines, Attenuated - administration & dosage Viral diseases Viral diseases of the digestive system
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