Regulation of mammalian iron homeostasis

Iron homeostasis is regulated with respect to uptake, storage and utilization. Newer work is presented that defines proteins responsible for iron transport, sequestration and sensing, and that addresses their regulation at the cellular and organismal levels by ambient iron concentrations, demand for...

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Veröffentlicht in:	Current opinion in clinical nutrition and metabolic care 2000-07, Vol.3 (4), p.267-273
Hauptverfasser:	Schneider, Brian D, Leibold, Elizabeth A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Homeostasis Humans Hypoxia - metabolism Intestinal Absorption Iron - metabolism Iron-Regulatory Proteins Iron-Sulfur Proteins - genetics Iron-Sulfur Proteins - metabolism Oxidative Stress Response Elements RNA - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism
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Beschreibung
Zusammenfassung:	Iron homeostasis is regulated with respect to uptake, storage and utilization. Newer work is presented that defines proteins responsible for iron transport, sequestration and sensing, and that addresses their regulation at the cellular and organismal levels by ambient iron concentrations, demand for erythropoiesis, body iron burden, and redox stimuli.
ISSN:	1363-1950 1473-6519
DOI:	10.1097/00075197-200007000-00005