High Plasma Levels of Factor VIII and the Risk of Recurrent Venous Thromboembolism
Elevated plasma levels of factor VIII are associated with an increased risk of venous thrombosis. 1 – 3 In the Leiden Thrombophilia Study, plasma levels of factor VIII above 150 IU per deciliter were associated with a quintupled risk of venous thrombosis, 1 an observation that was confirmed by anoth...
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| Veröffentlicht in: | The New England journal of medicine 2000-08, Vol.343 (7), p.457-462 |
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| container_title | The New England journal of medicine |
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| creator | Kyrle, Paul A Minar, Erich Hirschl, Mirko Bialonczyk, Christine Stain, Milena Schneider, Barbara Weltermann, Ansgar Speiser, Wolfgang Lechner, Klaus Eichinger, Sabine |
| description | Elevated plasma levels of factor VIII are associated with an increased risk of venous thrombosis.
1
–
3
In the Leiden Thrombophilia Study, plasma levels of factor VIII above 150 IU per deciliter were associated with a quintupled risk of venous thrombosis,
1
an observation that was confirmed by another study from the Netherlands.
3
Among patients with venous thrombosis, the prevalence of an elevated plasma level of factor VIII is approximately 20 percent.
2
,
3
High factor VIII levels persist over time,
3
,
4
are not attributable to an acute-phase reaction,
2
–
5
and may involve a genetic predisposition.
3
The mechanism by which a high factor . . . |
| doi_str_mv | 10.1056/NEJM200008173430702 |
| format | Article |
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1
–
3
In the Leiden Thrombophilia Study, plasma levels of factor VIII above 150 IU per deciliter were associated with a quintupled risk of venous thrombosis,
1
an observation that was confirmed by another study from the Netherlands.
3
Among patients with venous thrombosis, the prevalence of an elevated plasma level of factor VIII is approximately 20 percent.
2
,
3
High factor VIII levels persist over time,
3
,
4
are not attributable to an acute-phase reaction,
2
–
5
and may involve a genetic predisposition.
3
The mechanism by which a high factor . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM200008173430702</identifier><identifier>PMID: 10950667</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Anticoagulants ; Biological and medical sciences ; Blood clots ; Drug therapy ; Factor VIII - analysis ; Female ; Hematology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Plasma ; Prospective Studies ; Pulmonary Embolism - blood ; Recurrence ; Risk ; Risk Factors ; Ultrasonic imaging ; Veins & arteries ; Venous Thrombosis - blood</subject><ispartof>The New England journal of medicine, 2000-08, Vol.343 (7), p.457-462</ispartof><rights>Copyright © 2000 Massachusetts Medical Society. All rights reserved.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-8dfe5489e3258711cbcd8ea3dd5d475b5380d306f57d75343419a6762c2a99ac3</citedby><cites>FETCH-LOGICAL-c591t-8dfe5489e3258711cbcd8ea3dd5d475b5380d306f57d75343419a6762c2a99ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM200008173430702$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223956757?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1456911$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10950667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kyrle, Paul A</creatorcontrib><creatorcontrib>Minar, Erich</creatorcontrib><creatorcontrib>Hirschl, Mirko</creatorcontrib><creatorcontrib>Bialonczyk, Christine</creatorcontrib><creatorcontrib>Stain, Milena</creatorcontrib><creatorcontrib>Schneider, Barbara</creatorcontrib><creatorcontrib>Weltermann, Ansgar</creatorcontrib><creatorcontrib>Speiser, Wolfgang</creatorcontrib><creatorcontrib>Lechner, Klaus</creatorcontrib><creatorcontrib>Eichinger, Sabine</creatorcontrib><title>High Plasma Levels of Factor VIII and the Risk of Recurrent Venous Thromboembolism</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Elevated plasma levels of factor VIII are associated with an increased risk of venous thrombosis.
1
–
3
In the Leiden Thrombophilia Study, plasma levels of factor VIII above 150 IU per deciliter were associated with a quintupled risk of venous thrombosis,
1
an observation that was confirmed by another study from the Netherlands.
3
Among patients with venous thrombosis, the prevalence of an elevated plasma level of factor VIII is approximately 20 percent.
2
,
3
High factor VIII levels persist over time,
3
,
4
are not attributable to an acute-phase reaction,
2
–
5
and may involve a genetic predisposition.
3
The mechanism by which a high factor . . .</description><subject>Anticoagulants</subject><subject>Biological and medical sciences</subject><subject>Blood clots</subject><subject>Drug therapy</subject><subject>Factor VIII - analysis</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Pulmonary Embolism - blood</subject><subject>Recurrence</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Ultrasonic imaging</subject><subject>Veins & arteries</subject><subject>Venous Thrombosis - blood</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90F1LHDEUBuBQLHW1_oJCCaV4U8bmO5NLEa1bVlsW9XbIJmfc2U5m1mSm4L83yy4oIgZCLvKck5MXoS-UnFAi1c_r899XjORVUs0FJ5qwD2hCJeeFEETtoQkhrCyENnwfHaS02lgqzCe0T4mRRCk9QfPL5n6J_7Y2BYtn8B_ahPsaX1g39BHfTadTbDuPhyXgeZP-be7m4MYYoRvwHXT9mPDNMvZh0UPebZPCZ_Sxtm2Co915iG4vzm_OLovZn1_Ts9NZ4aShQ1H6GqQoDXAmS02pWzhfguXeSy-0XEheEs-JqqX2WuYPCmqs0oo5Zo2xjh-i423fdewfRkhDFZrkoG1tB3msSlMmhRYyw2-v4KofY5dnqxjjRiotdUZ8i1zsU4pQV-vYBBsfK0qqTd7VG3nnqq-71uMigH9Rsw04g-87YJOzbR1t55r07IRUhtLMfmxZCKnqYBXeffUJ5WORSA</recordid><startdate>20000817</startdate><enddate>20000817</enddate><creator>Kyrle, Paul A</creator><creator>Minar, Erich</creator><creator>Hirschl, Mirko</creator><creator>Bialonczyk, Christine</creator><creator>Stain, Milena</creator><creator>Schneider, Barbara</creator><creator>Weltermann, Ansgar</creator><creator>Speiser, Wolfgang</creator><creator>Lechner, Klaus</creator><creator>Eichinger, Sabine</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20000817</creationdate><title>High Plasma Levels of Factor VIII and the Risk of Recurrent Venous Thromboembolism</title><author>Kyrle, Paul A ; Minar, Erich ; Hirschl, Mirko ; Bialonczyk, Christine ; Stain, Milena ; Schneider, Barbara ; Weltermann, Ansgar ; Speiser, Wolfgang ; Lechner, Klaus ; Eichinger, Sabine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-8dfe5489e3258711cbcd8ea3dd5d475b5380d306f57d75343419a6762c2a99ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Anticoagulants</topic><topic>Biological and medical sciences</topic><topic>Blood clots</topic><topic>Drug therapy</topic><topic>Factor VIII - analysis</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Plasma</topic><topic>Prospective Studies</topic><topic>Pulmonary Embolism - blood</topic><topic>Recurrence</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Ultrasonic imaging</topic><topic>Veins & arteries</topic><topic>Venous Thrombosis - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kyrle, Paul A</creatorcontrib><creatorcontrib>Minar, Erich</creatorcontrib><creatorcontrib>Hirschl, Mirko</creatorcontrib><creatorcontrib>Bialonczyk, Christine</creatorcontrib><creatorcontrib>Stain, Milena</creatorcontrib><creatorcontrib>Schneider, Barbara</creatorcontrib><creatorcontrib>Weltermann, Ansgar</creatorcontrib><creatorcontrib>Speiser, Wolfgang</creatorcontrib><creatorcontrib>Lechner, Klaus</creatorcontrib><creatorcontrib>Eichinger, Sabine</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kyrle, Paul A</au><au>Minar, Erich</au><au>Hirschl, Mirko</au><au>Bialonczyk, Christine</au><au>Stain, Milena</au><au>Schneider, Barbara</au><au>Weltermann, Ansgar</au><au>Speiser, Wolfgang</au><au>Lechner, Klaus</au><au>Eichinger, Sabine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Plasma Levels of Factor VIII and the Risk of Recurrent Venous Thromboembolism</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2000-08-17</date><risdate>2000</risdate><volume>343</volume><issue>7</issue><spage>457</spage><epage>462</epage><pages>457-462</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Elevated plasma levels of factor VIII are associated with an increased risk of venous thrombosis.
1
–
3
In the Leiden Thrombophilia Study, plasma levels of factor VIII above 150 IU per deciliter were associated with a quintupled risk of venous thrombosis,
1
an observation that was confirmed by another study from the Netherlands.
3
Among patients with venous thrombosis, the prevalence of an elevated plasma level of factor VIII is approximately 20 percent.
2
,
3
High factor VIII levels persist over time,
3
,
4
are not attributable to an acute-phase reaction,
2
–
5
and may involve a genetic predisposition.
3
The mechanism by which a high factor . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>10950667</pmid><doi>10.1056/NEJM200008173430702</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2000-08, Vol.343 (7), p.457-462 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Anticoagulants Biological and medical sciences Blood clots Drug therapy Factor VIII - analysis Female Hematology Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Plasma Prospective Studies Pulmonary Embolism - blood Recurrence Risk Risk Factors Ultrasonic imaging Veins & arteries Venous Thrombosis - blood |
| title | High Plasma Levels of Factor VIII and the Risk of Recurrent Venous Thromboembolism |
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