EFFECTS OF PEROXYNITRITE ON PULMONARY EDEMA AND THE OXIDATIVE STATE

Excess nitric oxide (NO) generation in the presence of superoxide anion (O2-) leads to the formation of peroxynitrite which may result in lung injury. Oxidant-mediated lung injury has a critical role in pulmonary diseases. We therefore determined whether peroxynitrite causes lung fluid accumulation,...

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Veröffentlicht in:	Experimental lung research 2000, Vol.26 (5), p.349-359
Hauptverfasser:	BECKMAN, D. L, MEHTA, P, HANKS, V, ROWAN, W. H, LIN LIU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Bronchoalveolar Lavage Fluid Dose-Response Relationship, Drug Extravascular Lung Water - drug effects Lipid Peroxidation - drug effects Lung - drug effects Lung - metabolism Lung - pathology Male Medical sciences Nitrates - metabolism Nitrates - pharmacology Nitrotyrosine Peroxynitrite Pulmonary Edema Rat Lung Superoxide Organ Size - drug effects Perfusion Pneumology Pulmonary Edema - etiology Pulmonary Edema - metabolism Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Rats Rats, Sprague-Dawley Thiobarbituric Acid Reactive Substances - metabolism Tyrosine - analogs & derivatives Tyrosine - biosynthesis
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