Epidural infusion of ropivacaine for postoperative analgesia after major orthopedic surgery : Pharmacokinetic evaluation

Changing plasma protein concentrations may affect the protein binding and pharmacokinetics of drugs in the postoperative phase. Therefore, the authors evaluated the pharmacokinetics of ropivacaine, administered by 72-h epidural infusion to provide postoperative analgesia. Twenty-eight patients, sche...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2000-08, Vol.93 (2), p.395-403
Hauptverfasser:	BURM, A. G. L, STIENSTRA, R, BROUWER, R. P, EMANUELSSON, B.-M, VAN KLEEF, J. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amides - administration & dosage Amides - blood Amides - metabolism Amides - pharmacokinetics Amides - therapeutic use Analgesia, Epidural Analgesia, Patient-Controlled Anesthetics, Local - administration & dosage Anesthetics, Local - blood Anesthetics, Local - metabolism Anesthetics, Local - pharmacokinetics Anesthetics, Local - therapeutic use Anesthetics. Neuromuscular blocking agents Arthroplasty, Replacement, Hip Arthroplasty, Replacement, Knee Biological and medical sciences Biotransformation Humans Linear Models Medical sciences Metabolic Clearance Rate Middle Aged Neuropharmacology Orosomucoid - metabolism Pain Measurement Pain, Postoperative - prevention & control Pharmacology. Drug treatments Ropivacaine
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