Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1
6-Nitroquipazine has been known as one of the most potent and selective inhibitors of serotonin transporter in vitro and in vivo. Nine derivatives of 6-nitroquipazine were synthesized and tested for their potential abilities to displace [ 3H]citalopram binding to the rat cortical membranes.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2000-07, Vol.10 (14), p.1559-1562 |
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| container_end_page | 1562 |
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| container_issue | 14 |
| container_start_page | 1559 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 10 |
| creator | Lee, Byoung Se Chu, Soyoung Lee, Byung Chul Chi, Dae Yoon Choe, Yearn Seong Jeong, Kyung Ja Jin, Changbae |
| description | 6-Nitroquipazine has been known as one of the most potent and selective inhibitors of serotonin transporter in vitro and in vivo. Nine derivatives of 6-nitroquipazine were synthesized and tested for their potential abilities to displace [
3H]citalopram binding to the rat cortical membranes. |
| doi_str_mv | 10.1016/S0960-894X(00)00290-0 |
| format | Article |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Binding, Competitive Biological and medical sciences Carrier Proteins - metabolism Cell Membrane - metabolism Cerebral Cortex - metabolism Citalopram - pharmacokinetics Drug Design Indicators and Reagents Kinetics Medical sciences Membrane Glycoproteins - metabolism Membrane Transport Proteins Models, Structural Molecular Conformation Nerve Tissue Proteins Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Quipazine - analogs & derivatives Quipazine - chemical synthesis Quipazine - chemistry Quipazine - pharmacokinetics Quipazine - pharmacology Rats Serotonin Plasma Membrane Transport Proteins Serotonin Uptake Inhibitors - chemical synthesis Serotonin Uptake Inhibitors - chemistry Serotonin Uptake Inhibitors - pharmacokinetics Serotoninergic system Structure-Activity Relationship |
| title | Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1 |
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