Unexpected Structural Diversity in DNA Recombination: The Restriction Endonuclease Connection

Transposition requires a coordinated series of DNA breakage and joining reactions. The Tn7 transposase contains two proteins: TnsA, which carries out DNA breakage at the 5′ ends of the transposon, and TnsB, which carries out breakage and joining at the 3′ ends of the transposon. TnsB is a member of...

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Veröffentlicht in:	Molecular cell 2000-06, Vol.5 (6), p.1025-1034
Hauptverfasser:	Hickman, Alison Burgess, Li, Ying, Mathew, Shiny Varghese, May, Earl W, Craig, Nancy L, Dyda, Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Catalytic Domain Crystallography, X-Ray Deoxyribonucleases, Type II Site-Specific - chemistry DNA - genetics DNA - metabolism DNA Transposable Elements DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Escherichia coli Proteins Magnesium - metabolism Models, Molecular Mutation Protein Folding Protein Structure, Secondary Recombination, Genetic Structure-Activity Relationship TnsA protein transposase Transposases - chemistry Transposases - genetics Transposases - metabolism
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