Formation of multilamellar vesicles (‘onions’) in peptide based surfactant

Concentration dependent morphological characteristics of a novel dipeptide derivative Lys-Asp-Lauryl.HBr ( 1) has been presented. Evidence for “onion” like vesicle formation at higher concentration (>8.2×10 −3 M) of peptide ( 1) in aqueous medium was obtained from conductance and 90° light scatte...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-07, Vol.10 (14), p.1547-1550
Hauptverfasser:	Jayakumar, R, Murugesan, M, Ahmed, M.Rafiuddin
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Colloidal state and disperse state Cryoelectron Microscopy Dipeptides - chemical synthesis Dipeptides - chemistry Exact sciences and technology General and physical chemistry Lipoproteins - chemical synthesis Lipoproteins - chemistry Membranes Molecular Conformation Molecular Structure Solutions Surface-Active Agents - chemistry Water
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Zusammenfassung:	Concentration dependent morphological characteristics of a novel dipeptide derivative Lys-Asp-Lauryl.HBr ( 1) has been presented. Evidence for “onion” like vesicle formation at higher concentration (>8.2×10 −3 M) of peptide ( 1) in aqueous medium was obtained from conductance and 90° light scattering measurements, and cryo-transmission electron microscopic studies.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00289-4