Systemic production of human granulocyte colony-stimulating factor in nonhuman primates by transplantation of genetically modified myoblasts

Clinical use of human granulocyte-colony stimulating factor (hG-CSF) to treat various diseases involving neutropenia has been previously shown to (1) successfully increase circulating neutrophils, (2) reduce condition-related infections, and (3) cause few side effects in patients. To alleviate the s...

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Veröffentlicht in:	Human gene therapy 2000-06, Vol.11 (9), p.1277-1288
Hauptverfasser:	MOISSET, P.-A, BONHAM, L, SKUK, D, KOEBERL, D, BRUSSEE, V, GOULET, M, ROY, B, ASSELIN, I, MILLER, A. D, TREMBLAY, J. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Galactosidase - genetics Biological and medical sciences Biotechnology Cell Division Cell Transplantation Dystrophin - analysis Fundamental and applied biological sciences. Psychology Gene Expression Gene therapy Gene Transfer Techniques Granulocyte Colony-Stimulating Factor - genetics Granulocyte Colony-Stimulating Factor - metabolism Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Injections, Intramuscular Macaca mulatta Mice Mice, Inbred BALB C Mice, SCID Muscle, Skeletal - cytology Muscle, Skeletal - metabolism neutropenia Neutrophils - cytology Recombinant Proteins - metabolism Time Factors
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