A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells

Experimental autoimmune encephalomyelitis (EAE) is a prototype autoimmune disease mediated by type 1 helper T (T H 1) cells and under the control of regulatory cells 1 , 2 , 3 . Here we report that a synthetic glycolipid ligand for CD1d-restricted natural killer T (NKT) cells expressing the semi-inv...

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Veröffentlicht in:	Nature (London) 2001-10, Vol.413 (6855), p.531-534
Hauptverfasser:	Miyamoto, Katsuichi, Miyake, Sachiko, Yamamura, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, CD1 - immunology Antigens, CD1d Biological and medical sciences Encephalomyelitis, Autoimmune, Experimental - prevention & control Fundamental and applied biological sciences. Psychology Galactosylceramides - chemistry Glycolipids - chemistry Glycolipids - therapeutic use Humanities and Social Sciences Immunoglobulin G - immunology Interferon-gamma - biosynthesis Interferon-gamma - blood Interleukin-4 - biosynthesis Interleukin-4 - blood Killer Cells, Natural - immunology letter Ligands Lymphocyte Subsets - immunology Mice Molecular and cellular biology Molecular Sequence Data multidisciplinary Science Science (multidisciplinary) Th2 Cells - immunology
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