Transplantation of the bone marrow microenvironment leads to hematopoietic chimerism without cytoreductive conditioning

It has been hypothesized that regimens to induce transplantation tolerance and long-term hematopoietic chimerism require recipient conditioning with whole body irradiation or a cytoablative regimen to create space within the marrow microenvironment to permit pluripotent stem cell engraftment. The pu...

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Veröffentlicht in:	Transplantation 2000-06, Vol.69 (12), p.2491-2496
Hauptverfasser:	BINGAMAN, A. W, WAITZE, S.-Y, ALEXANDER, D. Z, HONG RAE CHO, LIN, A, TUCKER-BURDEN, C, COWAN, S. R, PEARSON, T. C, LARSEN, C. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Bone Transplantation Chimera Hematopoietic Stem Cells - physiology Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, SCID Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Conditioning
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