Methylation-dependent Silencing of the Testis-specific Pdha-2 Basal Promoter Occurs through Selective Targeting of an Activating Transcription Factor/cAMP-responsive Element-binding Site

In this study, we demonstrate that methylation-dependent repression of the Pdha-2core promoter is mediated regionally through a consensus activating transcription factor/cAMP-responsive element-binding site located between nucleotides −54 and −62 upstream of the major transcriptional start site. Tar...

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Veröffentlicht in:	The Journal of biological chemistry 2000-06, Vol.275 (26), p.19603-19608
Hauptverfasser:	Iannello, Rocco C., Gould, Jodee A., Young, Julia C., Giudice, Antonietta, Medcalf, Robert, Kola, Ismail
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Age Factors Animals Base Sequence Binding Sites Chloramphenicol O-Acetyltransferase - metabolism CpG Islands - physiology Cyclic AMP - metabolism Cyclic AMP Response Element Modulator DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation Gene Silencing Male Methylation Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Molecular Sequence Data Plasmids Promoter Regions, Genetic Protein Conformation Pyruvate Dehydrogenase (Lipoamide) Pyruvate Dehydrogenase Complex - chemistry Pyruvate Dehydrogenase Complex - genetics Pyruvate Dehydrogenase Complex - metabolism Repressor Proteins Response Elements - genetics Spermatogenesis - physiology Testis - metabolism Transcription Factors - metabolism Transcriptional Activation Transfection
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