Efficient adenoviral vector transduction of human hematopoietic SCID-repopulating and long-term culture-initiating cells

This article presents our studies on the adenoviral transduction efficiency, level of transgene expression, cell cycle status, and multilineage reconstitution ability of human CD34+ hematopoietic cells transduced under proliferating and survival growth conditions. Bone marrow and umbilical cord bloo...

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Veröffentlicht in:	Human gene therapy 2000-06, Vol.11 (9), p.1313-1327
Hauptverfasser:	XIAOLONG FAN, BRUN, A, SEGREN, S, JACOBSEN, S. E. W, KARLSSON, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenovirus ADP-ribosyl Cyclase ADP-ribosyl Cyclase 1 Animals Antigens, CD Antigens, CD34 - analysis Antigens, Differentiation - analysis Biological and medical sciences Biotechnology Bone Marrow Cells - cytology CD34 antigen Cell Division Cell Lineage Cell Survival Fetal Blood - cytology Fundamental and applied biological sciences. Psychology Gene Expression Gene therapy Genetic Vectors - genetics green fluorescent protein Green Fluorescent Proteins Health. Pharmaceutical industry Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - metabolism Humans Industrial applications and implications. Economical aspects Luminescent Proteins - genetics Membrane Glycoproteins Membrane Proteins - physiology Mice Mice, SCID NAD+ Nucleosidase - analysis Stem Cell Factor - physiology Thrombopoietin - physiology Transduction, Genetic
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