Sustained muscle contraction induced by agonists, growth factors, and Ca(2+) mediated by distinct PKC isozymes

The role of protein kinase C (PKC) in sustained contraction was examined in intestinal circular and longitudinal muscle cells. Initial contraction induced by agonists (CCK-8 and neuromedin C) was abolished by 1) inhibitors of Ca(2+) mobilization (neomycin and dimethyleicosadienoic acid), 2) calmidaz...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2000-07, Vol.279 (1), p.G201-G210
Hauptverfasser:	Murthy, K S, Grider, J R, Kuemmerle, J F, Makhlouf, G M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals Antibodies - pharmacology Benzophenanthridines Bombesin - pharmacology Calcium - metabolism Carbazoles Enzyme Inhibitors - pharmacology Epidermal Growth Factor - pharmacology Fatty Acids, Unsaturated - pharmacology Guinea Pigs Imidazoles - pharmacology In Vitro Techniques Indoles Intestines - cytology Isoenzymes - antagonists & inhibitors Isoenzymes - immunology Isoenzymes - metabolism Muscle Contraction - drug effects Muscle, Smooth - cytology Muscle, Smooth - enzymology Myosin-Light-Chain Kinase - antagonists & inhibitors Naphthalenes - pharmacology Neomycin - pharmacology Peptide Fragments - pharmacology Phenanthridines - pharmacology Phosphodiesterase Inhibitors - pharmacology Protein Kinase C - antagonists & inhibitors Protein Kinase C - immunology Protein Kinase C - metabolism Protein Kinase C beta Protein Kinase C-alpha Protein Kinase C-epsilon Protein Synthesis Inhibitors - pharmacology Sincalide - pharmacology
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