Ganglion cells in the posterior pituitary : result of ectopia or transdifferentiation?
Histologic examination revealed large ganglion cells within the posterior pituitary of an 80-year-old woman who died of myocardial infarction. Apparently fully mature, the cells were an incidental finding scattered within hyperplastic foci of pars intermedia (PI)-derived cells (basophil invasion) on...
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| Veröffentlicht in: | Acta neuropathologica 2000-07, Vol.100 (1), p.106-110 |
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| description | Histologic examination revealed large ganglion cells within the posterior pituitary of an 80-year-old woman who died of myocardial infarction. Apparently fully mature, the cells were an incidental finding scattered within hyperplastic foci of pars intermedia (PI)-derived cells (basophil invasion) on histologic examination of the pituitary obtained at autopsy. Immunocytochemistry showed staining reactivity for neuron-specific enolase, synaptophysin, alpha subunit of the glycoprotein hormones and beta-endorphin. The presence of these ganglion cells with features similar to those of magnocellular hypothalamic neurons could be considered the result of abnormal migration during the early phase of embryonic life, or differentiation/maturation of neuroblasts, presumed to occur in the embryonic neurohypophysis. Alternatively, transdifferentiation from proliferating PI cells may explain the emergence of neurons; a hypothesis supported by the proximity and shared alpha subunit, and beta-endorphin immunoreactivities of the two cell types. |
| doi_str_mv | 10.1007/s004010051200 |
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Alternatively, transdifferentiation from proliferating PI cells may explain the emergence of neurons; a hypothesis supported by the proximity and shared alpha subunit, and beta-endorphin immunoreactivities of the two cell types.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s004010051200</identifier><identifier>PMID: 10912928</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Aged ; Aged, 80 and over ; Autopsy ; Biological and medical sciences ; Cardiology. Vascular system ; Cell Differentiation - physiology ; Coronary heart disease ; Embryos ; Endorphins ; Female ; Ganglia - abnormalities ; Ganglia - pathology ; Ganglioglioma - etiology ; Ganglioglioma - pathology ; Ganglioglioma - physiopathology ; Ganglion cells ; Ganglioneuroma - etiology ; Ganglioneuroma - pathology ; Ganglioneuroma - physiopathology ; Heart ; Humans ; Hypothalamus ; Immunocytochemistry ; Leukocyte migration ; Medical sciences ; Metaplasia - metabolism ; Metaplasia - pathology ; Metaplasia - physiopathology ; Myocardial infarction ; Neuroblasts ; Neurons - metabolism ; Neurons - pathology ; Phosphopyruvate hydratase ; Pituitary (posterior) ; Pituitary Gland, Posterior - abnormalities ; Pituitary Gland, Posterior - pathology ; Pituitary Gland, Posterior - physiopathology ; Synaptophysin</subject><ispartof>Acta neuropathologica, 2000-07, Vol.100 (1), p.106-110</ispartof><rights>2000 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2000.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-80f08c9b21c5288d25c6560c4228fe4defdd90084cb73bffe3f1dc98affa6d2b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1418949$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10912928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HORVATH, E</creatorcontrib><creatorcontrib>KOVACS, K</creatorcontrib><creatorcontrib>TRAN, A</creatorcontrib><creatorcontrib>SCHEITHAUER, B. W</creatorcontrib><title>Ganglion cells in the posterior pituitary : result of ectopia or transdifferentiation?</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>Histologic examination revealed large ganglion cells within the posterior pituitary of an 80-year-old woman who died of myocardial infarction. Apparently fully mature, the cells were an incidental finding scattered within hyperplastic foci of pars intermedia (PI)-derived cells (basophil invasion) on histologic examination of the pituitary obtained at autopsy. Immunocytochemistry showed staining reactivity for neuron-specific enolase, synaptophysin, alpha subunit of the glycoprotein hormones and beta-endorphin. The presence of these ganglion cells with features similar to those of magnocellular hypothalamic neurons could be considered the result of abnormal migration during the early phase of embryonic life, or differentiation/maturation of neuroblasts, presumed to occur in the embryonic neurohypophysis. Alternatively, transdifferentiation from proliferating PI cells may explain the emergence of neurons; a hypothesis supported by the proximity and shared alpha subunit, and beta-endorphin immunoreactivities of the two cell types.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autopsy</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cell Differentiation - physiology</subject><subject>Coronary heart disease</subject><subject>Embryos</subject><subject>Endorphins</subject><subject>Female</subject><subject>Ganglia - abnormalities</subject><subject>Ganglia - pathology</subject><subject>Ganglioglioma - etiology</subject><subject>Ganglioglioma - pathology</subject><subject>Ganglioglioma - physiopathology</subject><subject>Ganglion cells</subject><subject>Ganglioneuroma - etiology</subject><subject>Ganglioneuroma - pathology</subject><subject>Ganglioneuroma - physiopathology</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Immunocytochemistry</subject><subject>Leukocyte migration</subject><subject>Medical sciences</subject><subject>Metaplasia - metabolism</subject><subject>Metaplasia - pathology</subject><subject>Metaplasia - physiopathology</subject><subject>Myocardial infarction</subject><subject>Neuroblasts</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Phosphopyruvate hydratase</subject><subject>Pituitary (posterior)</subject><subject>Pituitary Gland, Posterior - abnormalities</subject><subject>Pituitary Gland, Posterior - pathology</subject><subject>Pituitary Gland, Posterior - physiopathology</subject><subject>Synaptophysin</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkMtLxDAQh4Mo7rp69CoBxVt18mpTLyLiCwQv6rWkaaKRblOT9OB_b5Zd8HGaGfj4zcyH0CGBMwJQnUcADrkThAJsoTnhjBYgGNtGcwAgRckonaG9GD_yRCsudtGMQE1oTeUcvd6p4a13fsDa9H3EbsDp3eDRx2SC8wGPLk0uqfCFL3AwceoT9hYbnfzoFM5ACmqInbPWBDMkp1IOu9xHO1b10Rxs6gK93N48X98Xj093D9dXj4VmvEyFBAtS1y0lWlApOyp0KUrQnFJpDe-M7boaQHLdVqzNK5glna6lslaVHW3ZAp2uc8fgPycTU7N0cfWJGoyfYlMRykuRbSzQ8T_ww09hyLc1lBMhKiIkZKpYUzr4GIOxzRjcMj_fEGhWups_ujN_tEmd2qXpftFrvxk42QAqatXb7Eq7-MNxImtes29Reoc7</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>HORVATH, E</creator><creator>KOVACS, K</creator><creator>TRAN, A</creator><creator>SCHEITHAUER, B. 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Vascular system</topic><topic>Cell Differentiation - physiology</topic><topic>Coronary heart disease</topic><topic>Embryos</topic><topic>Endorphins</topic><topic>Female</topic><topic>Ganglia - abnormalities</topic><topic>Ganglia - pathology</topic><topic>Ganglioglioma - etiology</topic><topic>Ganglioglioma - pathology</topic><topic>Ganglioglioma - physiopathology</topic><topic>Ganglion cells</topic><topic>Ganglioneuroma - etiology</topic><topic>Ganglioneuroma - pathology</topic><topic>Ganglioneuroma - physiopathology</topic><topic>Heart</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Immunocytochemistry</topic><topic>Leukocyte migration</topic><topic>Medical sciences</topic><topic>Metaplasia - metabolism</topic><topic>Metaplasia - pathology</topic><topic>Metaplasia - physiopathology</topic><topic>Myocardial infarction</topic><topic>Neuroblasts</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>Phosphopyruvate hydratase</topic><topic>Pituitary (posterior)</topic><topic>Pituitary Gland, Posterior - abnormalities</topic><topic>Pituitary Gland, Posterior - pathology</topic><topic>Pituitary Gland, Posterior - physiopathology</topic><topic>Synaptophysin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HORVATH, E</creatorcontrib><creatorcontrib>KOVACS, K</creatorcontrib><creatorcontrib>TRAN, A</creatorcontrib><creatorcontrib>SCHEITHAUER, B. 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The presence of these ganglion cells with features similar to those of magnocellular hypothalamic neurons could be considered the result of abnormal migration during the early phase of embryonic life, or differentiation/maturation of neuroblasts, presumed to occur in the embryonic neurohypophysis. Alternatively, transdifferentiation from proliferating PI cells may explain the emergence of neurons; a hypothesis supported by the proximity and shared alpha subunit, and beta-endorphin immunoreactivities of the two cell types.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>10912928</pmid><doi>10.1007/s004010051200</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Autopsy Biological and medical sciences Cardiology. Vascular system Cell Differentiation - physiology Coronary heart disease Embryos Endorphins Female Ganglia - abnormalities Ganglia - pathology Ganglioglioma - etiology Ganglioglioma - pathology Ganglioglioma - physiopathology Ganglion cells Ganglioneuroma - etiology Ganglioneuroma - pathology Ganglioneuroma - physiopathology Heart Humans Hypothalamus Immunocytochemistry Leukocyte migration Medical sciences Metaplasia - metabolism Metaplasia - pathology Metaplasia - physiopathology Myocardial infarction Neuroblasts Neurons - metabolism Neurons - pathology Phosphopyruvate hydratase Pituitary (posterior) Pituitary Gland, Posterior - abnormalities Pituitary Gland, Posterior - pathology Pituitary Gland, Posterior - physiopathology Synaptophysin |
| title | Ganglion cells in the posterior pituitary : result of ectopia or transdifferentiation? |
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