Molecular cloning and functional characterization of murine Transmembrane Activator and CAML Interactor (TACI) with chromosomal localization in human and mouse

The human Taci gene (Transmembrane Activator and CAML Interactor) encodes a recently discovered member of the Tumor Necrosis Factor Receptor family. TACI is expressed in B-lymphocytes and may act to regulate humoral immunity. To identify functionally important regions of the protein, we have isolate...

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Veröffentlicht in:	Mammalian genome 2000-08, Vol.11 (8), p.628-632
Hauptverfasser:	von Bülow, Götz-Ulrich, Russell, Helen, Copeland, Neal G, Gilbert, Debra J, Jenkins, Nancy A, Bram, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals B-lymphocytes backcrossing Cell Line Chromosome 11 Chromosome 17 Chromosome Mapping chromosomes Chromosomes, Human, Pair 17 - genetics Cloning, Molecular complementary DNA DNA, Complementary - chemistry DNA, Complementary - genetics DNA, Complementary - isolation & purification DNA-Binding Proteins - genetics Dogs Female fluorescence in situ hybridization genes Humans humoral immunity In Situ Hybridization, Fluorescence Jurkat Cells Male Membrane Proteins Mice Mice, Inbred C57BL molecular cloning Molecular Sequence Data Muridae NF-^kB protein NF-kappa B - genetics NFAT protein NFATC Transcription Factors Nuclear Proteins Proteins Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - physiology Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid signal peptide Signal transduction Taci gene TACI protein Transcription Factor AP-1 - genetics transcription factors Transcription Factors - genetics Transcriptional Activation transfection Transmembrane Activator and CAML Interactor Protein tumor necrosis factors
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