Cutaneous T Cell Lymphoma Reactive CD4+ Cytotoxic T Lymphocyte Clones Display a Th1 Cytokine Profile and Use a Fas-Independent Pathway for Specific Tumor Cell Lysis

We have previously described two cytotoxic T lymphocyte clones isolated from lymphocytes infiltrating a human major histocompatibility complex class II–/class I+, CD4+ cutaneous T cell lymphoma. These clones displayed a CD4+CD8dim+ (TC5) and CD4+ CD8– (TC7) phenotype and mediated a specific major hi...

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Veröffentlicht in:	Journal of investigative dermatology 2000-07, Vol.115 (1), p.74-80
Hauptverfasser:	Echchakir, Hamid, Bagot, Martine, Dorothée, Guillaume, Martinvalet, Denis, Le Gouvello, Sabine, Boumsell, Laurence, Chouaib, Salem, Bensussan, Armand, Mami-Chouaib, Fathia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over AIDS/HIV Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Clone Cells CTCL cytokine profiles Cytokines - physiology cytotoxic pathways Dermatology fas Receptor - metabolism Granulocyte-Macrophage Colony-Stimulating Factor - physiology Humans Immunotherapy Interferon-gamma - physiology Interleukin-10 - physiology Interleukin-2 - physiology Interleukin-4 - physiology Interleukin-6 - physiology Lymphoma, T-Cell, Cutaneous - pathology Male Medical sciences Skin Neoplasms - pathology T-Lymphocytes, Cytotoxic - cytology Th1 Cells - secretion TIL Transforming Growth Factor beta - physiology Tumor Cells, Cultured Tumors of the skin and soft tissue. Premalignant lesions
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