Perinatal transmission of hepatitis B virus and its prevention

In order to prevent liver cirrhosis and hepatocellular carcinoma in later life, it is essential to prevent HBV infection in infants. If the mother is chronically infected with HBV and is also positive for HBeAg, 80–90% of the newborns become chronically infected, whereas if the mother is positive fo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of gastroenterology and hepatology 2000-05, Vol.15 (s2), p.E11-E15
1. Verfasser:	Shiraki, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier State - epidemiology Female Hepatitis B - epidemiology Hepatitis B - transmission Hepatitis B Surface Antigens - analysis Hepatitis B, Chronic - diagnosis Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - prevention & control Humans Immunization Immunoglobulins, Intravenous - administration & dosage Infant, Newborn Japan - epidemiology Pregnancy Pregnancy Complications, Infectious - diagnosis Taiwan - epidemiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In order to prevent liver cirrhosis and hepatocellular carcinoma in later life, it is essential to prevent HBV infection in infants. If the mother is chronically infected with HBV and is also positive for HBeAg, 80–90% of the newborns become chronically infected, whereas if the mother is positive for anti‐HBe, only some newborns will develop acute hepatitis or fulminant hepatitis. It is necessary to screen pregnant women for HBsAg and prevent mother‐to‐infant infection of HBV, treating the infant with hepatitis B hyperimmune globulin at birth, followed by HBV vaccination. In highly endemic areas of HBV, universal HBV vaccination of all newborns is advisable.
ISSN:	0815-9319 1440-1746
DOI:	10.1046/j.1440-1746.2000.02098.x