Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells

Mesangial cells (MC), grown on extracellular matrix (ECM) protein-coated plates and stretched, proliferate and produce ECM, recapitulating in vivo responses to increased glomerular capillary pressure (Pgc). Transduction of strain involves mitogen-activated protein kinases (MAPK), and we have shown t...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2000-08, Vol.279 (2), p.F243-F251
Hauptverfasser:	Ingram, A J, James, L, Thai, K, Ly, H, Cai, L, Scholey, J W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Cells, Cultured Cyclic GMP - pharmacology Enzyme Activation - physiology Enzyme Inhibitors - pharmacology Fluorescent Antibody Technique Glomerular Mesangium - enzymology Imidazoles - pharmacology Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Molsidomine - analogs & derivatives Molsidomine - pharmacology Nitric Oxide - physiology Nitric Oxide Donors - pharmacology p38 Mitogen-Activated Protein Kinases Penicillamine - analogs & derivatives Penicillamine - pharmacology Pyridines - pharmacology Rats Rats, Sprague-Dawley S-Nitroso-N-Acetylpenicillamine Signal Transduction - drug effects Space life sciences Stress, Mechanical
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