Amplification of the Human Dihydrofolate Reductase Gene via Double Minutes Is Initiated by Chromosome Breaks

DNA sequence amplification is one of the most frequent manifestations of genomic instability in human tumors. We have shown previously that amplification of the dihydrofolate reductase (DHFR) gene in Chinese hamster cells is initiated by chromosome breaks, followed by bridge-breakage-fusion cycles t...

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