Insulin-Like Growth Factor-I Promotes Myelination of Peripheral Sensory Axons

Insulin-like growth factor-I (IGF-I) in vivo or in the presence of other permissive factors can promote myelination in the central nervous system. In the current study, we examine the role of IGF-I in the myelination of peripheral nerves. In rat cocultures of dorsal root ganglia (DRG) and Schwann ce...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2000-07, Vol.59 (7), p.575-584
Hauptverfasser:	RUSSELL, JAMES W, CHENG, HSIN-LIN, GOLOVOY, DAVID
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Fetus - cytology Fundamental and applied biological sciences. Psychology Ganglia, Spinal - cytology Ganglia, Spinal - embryology Insulin-Like Growth Factor I - pharmacology Microscopy, Electron Myelin P0 Protein - biosynthesis Myelin proteins Myelin Sheath - drug effects Nerve Fibers, Myelinated - drug effects Nerve Fibers, Myelinated - metabolism Neurons, Afferent - drug effects Neurons, Afferent - physiology Neurons, Afferent - ultrastructure Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Rats Rats, Sprague-Dawley Schwann Cells - drug effects Schwann Cells - physiology Schwann Cells - ultrastructure Vertebrates: nervous system and sense organs
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