First Report Of Active Renin In Rat Amniotic Fluid
SUMMARY 1. Epidemiological studies indicate that a reduced birthweight increases the likelihood of human cardiovascular disease later in life. The role of hormonal factors in this finding is not known. Given that angiotensin II is believed to be a fetal regulator of growth, we have examined in the h...
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| Veröffentlicht in: | Clinical and Experimental Pharmacology and Physiology 2000-08, Vol.27 (8), p.631-633 |
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| container_title | Clinical and Experimental Pharmacology and Physiology |
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| creator | Caragounis, Aphrodite Koutsis, Kathy Wlodek, Mary E Wilkinson-Berka, Jennifer La Nicolantonio, Robert Di |
| description | SUMMARY
1. Epidemiological studies indicate that a reduced birthweight increases the likelihood of human cardiovascular disease later in life. The role of hormonal factors in this finding is not known. Given that angiotensin II is believed to be a fetal regulator of growth, we have examined in the hypertensive Ren‐2 transgenic rat whether it has active renin in its amniotic fluid and whether this is associated with fetal underdevelopment.
2. We found that while the Sprague‐Dawley rat contained no active renin in its amniotic fluid near term (20 days), Ren‐2 amniotic fluid contains high levels of active renin and is associated with a reduced fetal weight.
3. This is the first report of active renin in the rat and allows the possibility that renin overproduction plays a role in reduced fetal growth and the prenatal ‘programming’ of essential hypertension that has been proposed to occur in humans. |
| doi_str_mv | 10.1046/j.1440-1681.2000.03303.x |
| format | Article |
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1. Epidemiological studies indicate that a reduced birthweight increases the likelihood of human cardiovascular disease later in life. The role of hormonal factors in this finding is not known. Given that angiotensin II is believed to be a fetal regulator of growth, we have examined in the hypertensive Ren‐2 transgenic rat whether it has active renin in its amniotic fluid and whether this is associated with fetal underdevelopment.
2. We found that while the Sprague‐Dawley rat contained no active renin in its amniotic fluid near term (20 days), Ren‐2 amniotic fluid contains high levels of active renin and is associated with a reduced fetal weight.
3. This is the first report of active renin in the rat and allows the possibility that renin overproduction plays a role in reduced fetal growth and the prenatal ‘programming’ of essential hypertension that has been proposed to occur in humans.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1046/j.1440-1681.2000.03303.x</identifier><identifier>PMID: 10901395</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>amniotic fluid ; Amniotic Fluid - metabolism ; angiotensin ; Animals ; Animals, Genetically Modified ; Blood Pressure - genetics ; Blood Pressure - physiology ; Enzyme Precursors - blood ; Enzyme Precursors - genetics ; Female ; fetus ; hypertension ; intra-uterine growth retardation ; Mice ; Pregnancy ; prorenin ; Rats ; Rats, Sprague-Dawley ; Ren-2 ; renin ; Renin - blood ; Renin - genetics ; Renin - metabolism ; renin-angiotensin system</subject><ispartof>Clinical and Experimental Pharmacology and Physiology, 2000-08, Vol.27 (8), p.631-633</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3183-395c7abebc4266c8a3589f4969f25f8a333f008b904b930c950f23dbb75395de3</citedby><cites>FETCH-LOGICAL-c3183-395c7abebc4266c8a3589f4969f25f8a333f008b904b930c950f23dbb75395de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1440-1681.2000.03303.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1440-1681.2000.03303.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,1411,23909,23910,25118,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10901395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caragounis, Aphrodite</creatorcontrib><creatorcontrib>Koutsis, Kathy</creatorcontrib><creatorcontrib>Wlodek, Mary E</creatorcontrib><creatorcontrib>Wilkinson-Berka, Jennifer La</creatorcontrib><creatorcontrib>Nicolantonio, Robert Di</creatorcontrib><title>First Report Of Active Renin In Rat Amniotic Fluid</title><title>Clinical and Experimental Pharmacology and Physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1. Epidemiological studies indicate that a reduced birthweight increases the likelihood of human cardiovascular disease later in life. The role of hormonal factors in this finding is not known. Given that angiotensin II is believed to be a fetal regulator of growth, we have examined in the hypertensive Ren‐2 transgenic rat whether it has active renin in its amniotic fluid and whether this is associated with fetal underdevelopment.
2. We found that while the Sprague‐Dawley rat contained no active renin in its amniotic fluid near term (20 days), Ren‐2 amniotic fluid contains high levels of active renin and is associated with a reduced fetal weight.
3. This is the first report of active renin in the rat and allows the possibility that renin overproduction plays a role in reduced fetal growth and the prenatal ‘programming’ of essential hypertension that has been proposed to occur in humans.</description><subject>amniotic fluid</subject><subject>Amniotic Fluid - metabolism</subject><subject>angiotensin</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Blood Pressure - genetics</subject><subject>Blood Pressure - physiology</subject><subject>Enzyme Precursors - blood</subject><subject>Enzyme Precursors - genetics</subject><subject>Female</subject><subject>fetus</subject><subject>hypertension</subject><subject>intra-uterine growth retardation</subject><subject>Mice</subject><subject>Pregnancy</subject><subject>prorenin</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Ren-2</subject><subject>renin</subject><subject>Renin - blood</subject><subject>Renin - genetics</subject><subject>Renin - metabolism</subject><subject>renin-angiotensin system</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwkAUhidGI4i-gunKXeuZnk4vCxeEAKJEDNFg3Eza6TQZ7AU7ReHtnVpCXLqa2__9J_MRYlFwKHj-7dqhngc29UPquADgACKgszsh_ePDKekDArNpGECPXGi9NkEGPp6THoUIKEasT9yJqnVjLeWmqhtrkVlD0agvaS5KVVqz0lrGjTUsSlU1SliTfKvSS3KWxbmWV4d1QF4n45fRvT1fTGej4dwWSEO0Tb0I4kQmwnN9X4QxsjDKvMiPMpdl5oiYAYRJBF4SIYiIQeZimiQBM2gqcUBuut5NXX1upW54obSQeR6XstpqHlDXQ_MlEwy7oKgrrWuZ8U2tirjecwq89cXXvNXCWy289cV_ffGdQa8PM7ZJIdM_YCfIBO66wLfK5f7fxXw0fm53hrc7XulG7o58XH9wP8CA8dXTlD_MVxOfvT_yN_wB7WiFRg</recordid><startdate>200008</startdate><enddate>200008</enddate><creator>Caragounis, Aphrodite</creator><creator>Koutsis, Kathy</creator><creator>Wlodek, Mary E</creator><creator>Wilkinson-Berka, Jennifer La</creator><creator>Nicolantonio, Robert Di</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200008</creationdate><title>First Report Of Active Renin In Rat Amniotic Fluid</title><author>Caragounis, Aphrodite ; Koutsis, Kathy ; Wlodek, Mary E ; Wilkinson-Berka, Jennifer La ; Nicolantonio, Robert Di</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3183-395c7abebc4266c8a3589f4969f25f8a333f008b904b930c950f23dbb75395de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>amniotic fluid</topic><topic>Amniotic Fluid - metabolism</topic><topic>angiotensin</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Blood Pressure - genetics</topic><topic>Blood Pressure - physiology</topic><topic>Enzyme Precursors - blood</topic><topic>Enzyme Precursors - genetics</topic><topic>Female</topic><topic>fetus</topic><topic>hypertension</topic><topic>intra-uterine growth retardation</topic><topic>Mice</topic><topic>Pregnancy</topic><topic>prorenin</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Ren-2</topic><topic>renin</topic><topic>Renin - blood</topic><topic>Renin - genetics</topic><topic>Renin - metabolism</topic><topic>renin-angiotensin system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caragounis, Aphrodite</creatorcontrib><creatorcontrib>Koutsis, Kathy</creatorcontrib><creatorcontrib>Wlodek, Mary E</creatorcontrib><creatorcontrib>Wilkinson-Berka, Jennifer La</creatorcontrib><creatorcontrib>Nicolantonio, Robert Di</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and Experimental Pharmacology and Physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caragounis, Aphrodite</au><au>Koutsis, Kathy</au><au>Wlodek, Mary E</au><au>Wilkinson-Berka, Jennifer La</au><au>Nicolantonio, Robert Di</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First Report Of Active Renin In Rat Amniotic Fluid</atitle><jtitle>Clinical and Experimental Pharmacology and Physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>2000-08</date><risdate>2000</risdate><volume>27</volume><issue>8</issue><spage>631</spage><epage>633</epage><pages>631-633</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY
1. Epidemiological studies indicate that a reduced birthweight increases the likelihood of human cardiovascular disease later in life. The role of hormonal factors in this finding is not known. Given that angiotensin II is believed to be a fetal regulator of growth, we have examined in the hypertensive Ren‐2 transgenic rat whether it has active renin in its amniotic fluid and whether this is associated with fetal underdevelopment.
2. We found that while the Sprague‐Dawley rat contained no active renin in its amniotic fluid near term (20 days), Ren‐2 amniotic fluid contains high levels of active renin and is associated with a reduced fetal weight.
3. This is the first report of active renin in the rat and allows the possibility that renin overproduction plays a role in reduced fetal growth and the prenatal ‘programming’ of essential hypertension that has been proposed to occur in humans.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>10901395</pmid><doi>10.1046/j.1440-1681.2000.03303.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | Clinical and Experimental Pharmacology and Physiology, 2000-08, Vol.27 (8), p.631-633 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | amniotic fluid Amniotic Fluid - metabolism angiotensin Animals Animals, Genetically Modified Blood Pressure - genetics Blood Pressure - physiology Enzyme Precursors - blood Enzyme Precursors - genetics Female fetus hypertension intra-uterine growth retardation Mice Pregnancy prorenin Rats Rats, Sprague-Dawley Ren-2 renin Renin - blood Renin - genetics Renin - metabolism renin-angiotensin system |
| title | First Report Of Active Renin In Rat Amniotic Fluid |
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