Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons

The genetic modification of pigs is a powerful strategy that may ultimately enable successful xenotransplantation of porcine organs into humans. Transgenic pigs were produced by microinjection of gene constructs for human complement regulatory proteins CD55 and CD59 and the enzyme alpha1,2-fucosyltr...

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Veröffentlicht in:	Transplantation 2000-06, Vol.69 (12), p.2504-2515
Hauptverfasser:	COWAN, P. J, AMINIAN, A, NOTTLE, M. B, PEARSE, M. J, SALVARIS, E, SHINKEL, T. A, STAINSBY, G. V, STEWART, A. B, D'APICE, A. J. F, BARLOW, H, BROWN, A. A, CHEN, C.-G, FISICARO, N, FRANCIS, D. M. A, GOODMAN, D. J, WENRUO HAN, KUREK, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Coagulation Disorders - etiology CD55 antigen CD59 antigen CD59 Antigens - analysis CD59 Antigens - genetics CD59 Antigens - physiology Fucosyltransferases - genetics Fucosyltransferases - physiology Galactoside 2-alpha-L-fucosyltransferase Graft Rejection Immunohistochemistry Immunosuppression Therapy Kidney - pathology Kidney Transplantation - adverse effects Kidney Transplantation - immunology Medical sciences Mice Papio Papio cynocephalus anubis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Swine Transplantation, Heterologous - immunology
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