Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation

Germline mutations in the BRCA1 and BRCA2 genes highly predispose to breast and ovarian cancer. In families with BRCA1 or BRCA2 mutations, identification of mutation carriers is clinically relevant in view of the options for surveillance and prevention. We assessed presymptomatic DNA testing and pro...

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