Immunosuppressive Effect of CTLA-4 Blockade and Regulatory Role of CD8 T Cells in Th2-mediated Humoral Immune Responses

CTLA-4 is a negative regulator for T cell activation and plays an important role in down-regulating immune responses and the maintenance of peripheral tolerance. The effect of initial treatment with anti-CTLA-4 mAb on murine acute and chronic graft-versus-host diseases (GVHD) induced by transfer of...

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Veröffentlicht in:	Kōkūbyō Gakkai Zasshi JAPAN, 2000/06/30, Vol.67(2), pp.146-154
1. Verfasser:	Sakurai, Jinkyo
Format:	Artikel
Sprache:	jpn
Schlagworte:	Abatacept AIDS/HIV Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibody Formation - immunology Antigens, CD Antigens, Differentiation - pharmacology CD8-Positive T-Lymphocytes - physiology CTLA-4 Antigen Dentistry Female Graft vs Host Disease - immunology Graft vs Host Disease - therapy Immunoconjugates Immunoglobulin E - metabolism Immunosuppressive Agents - pharmacology Interferon-gamma - metabolism Interleukin-4 - metabolism Mice Mice, Inbred Strains Signal Transduction Th2 Cells - immunology
Online-Zugang:	Volltext
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