Histamine as an autocrine growth factor: an unusual role for a widespread mediator
The involvement of histamine in cancer growth represents an old controversy and direct experimental evidence proving this hypothesis is not still available. In this paper we review the most relevant mechanisms referring to the role of histamine receptors, histidine decarboxylase and histamine releas...
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| Veröffentlicht in: | Seminars in cancer biology 2000-02, Vol.10 (1), p.15-23 |
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| container_title | Seminars in cancer biology |
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| creator | Rivera, Elena S. Cricco, Graciela P. Engel, Nora I. Fitzsimons, Carlos P. Martı́n, Gabriela A. Bergoc, Rosa M. |
| description | The involvement of histamine in cancer growth represents an old controversy and direct experimental evidence proving this hypothesis is not still available. In this paper we review the most relevant mechanisms referring to the role of histamine receptors, histidine decarboxylase and histamine release in the onset of an autocrine loop, that enables histamine to act as an autocrine growth factor. We postulate that this autocrine loop, that has been studied in an experimental mammary carcinoma model induced in rats, may be present in different human neoplasias. Therefore, the better understanding of this novel regulatory pathway that is controlled by histamine may contribute to identifying new therapeutic targets. |
| doi_str_mv | 10.1006/scbi.2000.0303 |
| format | Article |
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Therefore, the better understanding of this novel regulatory pathway that is controlled by histamine may contribute to identifying new therapeutic targets.</description><subject>Animals</subject><subject>Autocrine Communication - physiology</subject><subject>Growth Substances - physiology</subject><subject>Histamine - physiology</subject><subject>histamine / histamine receptors / histidine decarboxylase (HDC) / growth factors / NMU-induced carcinomas</subject><subject>Histamine Release</subject><subject>histidine decarboxylase</subject><subject>Histidine Decarboxylase - metabolism</subject><subject>Mice</subject><subject>Neoplasms - metabolism</subject><subject>Rats</subject><subject>Receptors, Histamine - metabolism</subject><issn>1044-579X</issn><issn>1096-3650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtrGzEURkVoiZ3HtsugVXfjXD08krIrpnmAIRBa6E5IGqlVGY8caaam_74a7EU2Jauri44-8R2EPhFYEYD2tjgbVxQAVsCAnaElAdU2rF3Dh_nMebMW6scCXZTyu1KKE36OFgSklLQVS_TyGMtodnHw2BRsBmymMbk87z9zOoy_cDBuTPluvpuGqUymxzn1HoeUscGH2Pmyz950eOe7aCp6hT4G0xd_fZqX6Pv912-bx2b7_PC0-bJtHGdibEjHHeO8pRygVqFMWRLAMkUsUYJSQXiQTlAbiKRWdUEa3kpFfLDMgufsEn0-5u5zep18GfUuFuf73gw-TUULQplQFN4FiRD1V7mu4OoIupxKyT7ofY47k_9qAnrWrWfdetatZ931wc0pebK1_hv86LcC8gj4KuJP9LkmRD-4qip7N-ouxf9l_wPRIY1x</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Rivera, Elena S.</creator><creator>Cricco, Graciela P.</creator><creator>Engel, Nora I.</creator><creator>Fitzsimons, Carlos P.</creator><creator>Martı́n, Gabriela A.</creator><creator>Bergoc, Rosa M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>Histamine as an autocrine growth factor: an unusual role for a widespread mediator</title><author>Rivera, Elena S. ; Cricco, Graciela P. ; Engel, Nora I. ; Fitzsimons, Carlos P. ; Martı́n, Gabriela A. ; Bergoc, Rosa M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-1d4c34462400100239b1f0b391b19722714f8c72bf182b9df8a46891efb3b0e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Autocrine Communication - physiology</topic><topic>Growth Substances - physiology</topic><topic>Histamine - physiology</topic><topic>histamine / histamine receptors / histidine decarboxylase (HDC) / growth factors / NMU-induced carcinomas</topic><topic>Histamine Release</topic><topic>histidine decarboxylase</topic><topic>Histidine Decarboxylase - metabolism</topic><topic>Mice</topic><topic>Neoplasms - metabolism</topic><topic>Rats</topic><topic>Receptors, Histamine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rivera, Elena S.</creatorcontrib><creatorcontrib>Cricco, Graciela P.</creatorcontrib><creatorcontrib>Engel, Nora I.</creatorcontrib><creatorcontrib>Fitzsimons, Carlos P.</creatorcontrib><creatorcontrib>Martı́n, Gabriela A.</creatorcontrib><creatorcontrib>Bergoc, Rosa M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in cancer biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rivera, Elena S.</au><au>Cricco, Graciela P.</au><au>Engel, Nora I.</au><au>Fitzsimons, Carlos P.</au><au>Martı́n, Gabriela A.</au><au>Bergoc, Rosa M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histamine as an autocrine growth factor: an unusual role for a widespread mediator</atitle><jtitle>Seminars in cancer biology</jtitle><addtitle>Semin Cancer Biol</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>10</volume><issue>1</issue><spage>15</spage><epage>23</epage><pages>15-23</pages><issn>1044-579X</issn><eissn>1096-3650</eissn><abstract>The involvement of histamine in cancer growth represents an old controversy and direct experimental evidence proving this hypothesis is not still available. 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| identifier | ISSN: 1044-579X |
| ispartof | Seminars in cancer biology, 2000-02, Vol.10 (1), p.15-23 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Autocrine Communication - physiology Growth Substances - physiology Histamine - physiology histamine / histamine receptors / histidine decarboxylase (HDC) / growth factors / NMU-induced carcinomas Histamine Release histidine decarboxylase Histidine Decarboxylase - metabolism Mice Neoplasms - metabolism Rats Receptors, Histamine - metabolism |
| title | Histamine as an autocrine growth factor: an unusual role for a widespread mediator |
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