Nitric Oxide Synthase/COX Cross-Talk: Nitric Oxide Activates COX-1 But Inhibits COX-2-Derived Prostaglandin Production

It is recognized that there is molecular cross-talk between the inflammatory mediators NO and PGs that may regulate tissue homeostasis and contribute to pathophysiological processes. However, the literature is divided with respect to whether NO activates or inhibits PG production. In this study, we...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-08, Vol.165 (3), p.1582-1587
Hauptverfasser:	Clancy, Robert, Varenika, Branko, Huang, Weiqing, Ballou, Les, Attur, Mukundan, Amin, Ashok R, Abramson, Steven B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Communication - immunology Cell Line Cell Line, Transformed Cyclooxygenase 1 Cyclooxygenase 2 Dinoprostone - antagonists & inhibitors Dinoprostone - biosynthesis Fibroblasts - enzymology Fibroblasts - metabolism Interphase - immunology Isoenzymes - antagonists & inhibitors Isoenzymes - deficiency Isoenzymes - genetics Isoenzymes - metabolism Lipopolysaccharides - pharmacology Macrophage Activation - immunology Macrophages - enzymology Macrophages - metabolism Membrane Proteins Mice Nitrates - metabolism Nitric Oxide - physiology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Prostaglandin Antagonists - metabolism Prostaglandin-Endoperoxide Synthases - deficiency Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins - biosynthesis Up-Regulation - immunology
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