Human Neural Precursor Cells Express Low Levels of Telomerase in Vitro and Show Diminishing Cell Proliferation with Extensive Axonal Outgrowth following Transplantation

Worldwideattention is presently focused on proliferating populations of neural precursor cells as an in vitro source of tissue for neural transplantation and brain repair. However, successful neuroreconstruction is contingent upon their capacity to integrate within the host CNS and the absence of tu...

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Veröffentlicht in:	Experimental neurology 2000-07, Vol.164 (1), p.215-226
Hauptverfasser:	Ostenfeld, Thor, Caldwell, Maeve A., Prowse, Karen R., Linskens, Maarten H., Jauniaux, Eric, Svendsen, Clive N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - metabolism Axons - ultrastructure Biological and medical sciences Brain Tissue Transplantation Cell Count Cell Differentiation cell division Cell Division - drug effects Cell Movement - drug effects Cells, Cultured Corpus Striatum - drug effects Corpus Striatum - metabolism Development. Senescence. Regeneration. Transplantation Female Fetal Tissue Transplantation Fibroblast Growth Factor 2 - pharmacology Fundamental and applied biological sciences. Psychology Graft Survival human Humans immune rejection Nerve Fibers - metabolism neural precursor cells neural progenitor cells neural stem cells neural transplantation Neurons - cytology Neurons - drug effects Neurons - enzymology Neurons - transplantation Oxidopamine Rats Stem Cell Transplantation Stem Cells - cytology Stem Cells - drug effects Stem Cells - enzymology telomerase Telomerase - biosynthesis Telomere - ultrastructure telomeres Time Transplantation, Heterologous Tubulin - metabolism Tyrosine 3-Monooxygenase - metabolism Vertebrates: nervous system and sense organs
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