Cloning, Characterization and Heterologous Expression of a Polyketide Synthase and P-450 Oxidase Involved in the Biosynthesis of the Antibiotic Oleandomycin

The gene cluster encoding the deoxyoleandolide polyketide synthase (OlePKS) was isolated from the oleandomycin producing strain Streptomyces antibioticus. Sequencing of the first two genes encoding OlePKS, together with the previously identified third gene revealed an overall genetic and protein arc...

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Veröffentlicht in:	Journal of antibiotics 2000/05/25, Vol.53(5), pp.502-508
Hauptverfasser:	SHAH, SANJAY, XUE, QUN, TANG, LI, CARNEY, JOHN R., BETLACH, MARY, MCDANIEL, ROBERT
Format:	Artikel
Sprache:	eng
Schlagworte:	6-deoxyerythronolide B synthase Anti-Bacterial Agents - biosynthesis Base Sequence Cloning, Molecular deoxyoleandolide polyketide synthase DNA Primers Epoxy Compounds - metabolism erythromycin Genes, Bacterial Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Multigene Family NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - metabolism NADPH-Ferrihemoprotein Reductase Oleandomycin Oleandomycin - biosynthesis Saccharopolyspora erythraea Streptomyces - metabolism Streptomyces antibioticus Streptomyces lividans
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