Venous Thrombotic Risk in Family Members of Unselected Individuals with Factor V Leiden

Summary The factor V Leiden mutation (FVL) leads to a seven-fold increased risk of venous thromboembolism (VTE). In thrombophilic families, 25% of carriers have experienced thrombosis before the age of 40 years. Aim of our study was to assess the association of FVL with VTE in first-degree family me...

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Veröffentlicht in:	Thrombosis and haemostasis 2000-06, Vol.83 (6), p.817-821
Hauptverfasser:	Lensen, R. P. M., Bertina, R. M., de Ronde, H., Vandenbroucke, J. P., Rosendaal, F. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Commentary Disease-Free Survival Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Factor V - adverse effects Family Health Female Follow-Up Studies Hematologic and hematopoietic diseases Heterozygote Homozygote Humans Incidence Medical sciences Middle Aged Multivariate Analysis Platelet diseases and coagulopathies Pregnancy Pregnancy Complications, Cardiovascular - etiology Recurrence Risk Factors Thromboembolism - epidemiology Thromboembolism - etiology Thromboembolism - genetics Thrombophilia - epidemiology Thrombophilia - etiology Thrombophilia - genetics Venous Thrombosis - epidemiology Venous Thrombosis - etiology Venous Thrombosis - genetics
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