8-Chloro-cAMP inhibits smooth muscle cell proliferation in vitro and neointima formation induced by balloon injury in vivo

OBJECTIVES The aims of the present study were to assess 1) the effect of 8-Cl-cAMP (cyclic-3′-5′-adenosine monophosphate) on vascular smooth muscle cell (VSMC) proliferation in vitro and 2) the efficacy of systemic administration of 8-Cl-cAMP on neointimal formation after balloon injury in vivo. BAC...

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Veröffentlicht in:	Journal of the American College of Cardiology 2000-07, Vol.36 (1), p.288-293
Hauptverfasser:	Indolfi, Ciro, Di Lorenzo, Emilio, Rapacciuolo, Antonio, Stingone, Angela Maria, Stabile, Eugenio, Leccia, Antonio, Torella, Daniele, Caputo, Rosa, Ciardiello, Fortunato, Tortora, Gianpaolo, Chiariello, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - administration & dosage 8-Bromo Cyclic Adenosine Monophosphate - analogs & derivatives 8-Bromo Cyclic Adenosine Monophosphate - pharmacology Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Aorta, Thoracic - injuries Aorta, Thoracic - pathology Arterial Occlusive Diseases - enzymology Arterial Occlusive Diseases - metabolism Arterial Occlusive Diseases - prevention & control Biological and medical sciences Blood Pressure - drug effects Catheterization - adverse effects Cell Division - drug effects Cells, Cultured Cyclic AMP-Dependent Protein Kinase RIalpha Subunit Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit Cyclic AMP-Dependent Protein Kinases - metabolism Diseases of the cardiovascular system Down-Regulation - drug effects Heart Rate - drug effects Injections, Intraperitoneal Medical sciences Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Wistar Tunica Intima - cytology Tunica Intima - drug effects Tunica Intima - enzymology Up-Regulation - drug effects
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