Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis
Background/Aim: Serum levels of leptin, the adipocyte-derived hormone regulating food intake and energy expenditure in mammals, have been found to be increased in cirrhotic patients. The aim of the present study was to investigate leptin serum level in relation to anthropometric features and liver f...
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| Veröffentlicht in: | Journal of hepatology 2000-07, Vol.33 (1), p.33-37 |
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| creator | Testa, Roberto Franceschini, Roberto Giannini, Edoardo Cataldi, Angelo Botta, Federica Fasoli, Alberto Tenerelli, Pasquale Rolandi, Ermanno Barreca, Tommaso |
| description | Background/Aim: Serum levels of leptin, the adipocyte-derived hormone regulating food intake and energy expenditure in mammals, have been found to be increased in cirrhotic patients. The aim of the present study was to investigate leptin serum level in relation to anthropometric features and liver function in patients with viral chronic hepatitis or liver cirrhosis.
Methods: Serum leptin levels were determined by radioimmunoassay in 30 male and 10 female patients with chronic hepatitis, in 42 male and 10 female patients with liver cirrhosis, and in four respective control groups. Liver function was evaluated by the monoethylglycinexylidide formation test. Body mass index and body fat mass were estimated by weight, height and skinfold thickness measurements.
Results: Compared with controls, absolute serum leptin levels were significantly (
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| doi_str_mv | 10.1016/S0168-8278(00)80156-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71233424</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168827800801567</els_id><sourcerecordid>71233424</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-2d592e67a73c8dce3501216bbd9670d70b921fc5f7311ae4619d9bc429aa74c13</originalsourceid><addsrcrecordid>eNqFkEtLxDAQgIMo7vr4CUoOInqoTpq2aU4iiy9Y2MPqOaTplEa67Zp0V_z3ZreLevMyMzDfPPgIOWNww4Blt_MQ8iiPRX4FcJ0DS7NI7JExywAiyBK2T8Y_yIgcef8OABxkckhGDCSkac7HZDZHt1rQBpe9bUNaY-NpqJa6t9j2nn7avqZr63RDTe261hpa46bbW087Rxu7RkeNda7uvPUn5KDSjcfTXT4mb48Pr5PnaDp7epncTyPDJfRRXKYyxkxowU1eGuQpsJhlRVHKTEApoJAxq0xaCc6YxiRjspSFSWKptUgM48fkcti7dN3HCn2vFtYbbBrdYrfySrCY8yROApgOoHGd9w4rtXR2od2XYqA2JtXWpNpoUgBqa1KJMHe-O7AqFlj-mRrUBeBiB2hvdFM53Rrrfzme54LLgN0NWBCLa4tOeRPMGiytQ9OrsrP_fPINkeiP5g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71233424</pqid></control><display><type>article</type><title>Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Testa, Roberto ; Franceschini, Roberto ; Giannini, Edoardo ; Cataldi, Angelo ; Botta, Federica ; Fasoli, Alberto ; Tenerelli, Pasquale ; Rolandi, Ermanno ; Barreca, Tommaso</creator><creatorcontrib>Testa, Roberto ; Franceschini, Roberto ; Giannini, Edoardo ; Cataldi, Angelo ; Botta, Federica ; Fasoli, Alberto ; Tenerelli, Pasquale ; Rolandi, Ermanno ; Barreca, Tommaso</creatorcontrib><description>Background/Aim: Serum levels of leptin, the adipocyte-derived hormone regulating food intake and energy expenditure in mammals, have been found to be increased in cirrhotic patients. The aim of the present study was to investigate leptin serum level in relation to anthropometric features and liver function in patients with viral chronic hepatitis or liver cirrhosis.
Methods: Serum leptin levels were determined by radioimmunoassay in 30 male and 10 female patients with chronic hepatitis, in 42 male and 10 female patients with liver cirrhosis, and in four respective control groups. Liver function was evaluated by the monoethylglycinexylidide formation test. Body mass index and body fat mass were estimated by weight, height and skinfold thickness measurements.
Results: Compared with controls, absolute serum leptin levels were significantly (
p<0.01) lower in chronic hepatitis patients and similar in cirrhotic patients. Leptin serum levels were significantly (
p<0.05) higher in cirrhotic than in chronic hepatitis patients. When expressed in relation to body fat mass, the above differences persisted; however, cirrhotic females showed significantly (
p<0;0.05) higher serum leptin values than controls. Serum leptin values correlated negatively (
p<0;0.01) with monoethylglycinexylidide serum values in all groups of patients.
Conclusions: In patients with chronic viral liver disease, serum leptin levels tend to increase as liver function worsens. This may reflect a decline in the ability to downregulate energy expenditure as an adaptation to anorexia and/or to defective substrate utilisation due to liver disease and may negatively influence body weight homeostasis in these patients.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(00)80156-7</identifier><identifier>PMID: 10905583</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adipose Tissue - pathology ; Adult ; Biological and medical sciences ; Chronic viral hepatitis ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis B, Chronic - blood ; Hepatitis B, Chronic - complications ; Hepatitis B, Chronic - pathology ; Hepatitis C, Chronic - blood ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - pathology ; Humans ; Leptin ; Leptin - blood ; Lidocaine - analogs & derivatives ; Lidocaine - blood ; Liver cirrhosis ; Liver Cirrhosis - blood ; Liver Cirrhosis - pathology ; Liver Cirrhosis - virology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; MEGX30 ; Middle Aged ; Organ Size ; Other diseases. Semiology ; Reference Values</subject><ispartof>Journal of hepatology, 2000-07, Vol.33 (1), p.33-37</ispartof><rights>2000</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-2d592e67a73c8dce3501216bbd9670d70b921fc5f7311ae4619d9bc429aa74c13</citedby><cites>FETCH-LOGICAL-c390t-2d592e67a73c8dce3501216bbd9670d70b921fc5f7311ae4619d9bc429aa74c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168827800801567$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1388739$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10905583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Testa, Roberto</creatorcontrib><creatorcontrib>Franceschini, Roberto</creatorcontrib><creatorcontrib>Giannini, Edoardo</creatorcontrib><creatorcontrib>Cataldi, Angelo</creatorcontrib><creatorcontrib>Botta, Federica</creatorcontrib><creatorcontrib>Fasoli, Alberto</creatorcontrib><creatorcontrib>Tenerelli, Pasquale</creatorcontrib><creatorcontrib>Rolandi, Ermanno</creatorcontrib><creatorcontrib>Barreca, Tommaso</creatorcontrib><title>Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Background/Aim: Serum levels of leptin, the adipocyte-derived hormone regulating food intake and energy expenditure in mammals, have been found to be increased in cirrhotic patients. The aim of the present study was to investigate leptin serum level in relation to anthropometric features and liver function in patients with viral chronic hepatitis or liver cirrhosis.
Methods: Serum leptin levels were determined by radioimmunoassay in 30 male and 10 female patients with chronic hepatitis, in 42 male and 10 female patients with liver cirrhosis, and in four respective control groups. Liver function was evaluated by the monoethylglycinexylidide formation test. Body mass index and body fat mass were estimated by weight, height and skinfold thickness measurements.
Results: Compared with controls, absolute serum leptin levels were significantly (
p<0.01) lower in chronic hepatitis patients and similar in cirrhotic patients. Leptin serum levels were significantly (
p<0.05) higher in cirrhotic than in chronic hepatitis patients. When expressed in relation to body fat mass, the above differences persisted; however, cirrhotic females showed significantly (
p<0;0.05) higher serum leptin values than controls. Serum leptin values correlated negatively (
p<0;0.01) with monoethylglycinexylidide serum values in all groups of patients.
Conclusions: In patients with chronic viral liver disease, serum leptin levels tend to increase as liver function worsens. This may reflect a decline in the ability to downregulate energy expenditure as an adaptation to anorexia and/or to defective substrate utilisation due to liver disease and may negatively influence body weight homeostasis in these patients.</description><subject>Adipose Tissue - pathology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chronic viral hepatitis</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis B, Chronic - blood</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Hepatitis C, Chronic - blood</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - pathology</subject><subject>Humans</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Lidocaine - analogs & derivatives</subject><subject>Lidocaine - blood</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver Cirrhosis - virology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEGX30</subject><subject>Middle Aged</subject><subject>Organ Size</subject><subject>Other diseases. Semiology</subject><subject>Reference Values</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo7vr4CUoOInqoTpq2aU4iiy9Y2MPqOaTplEa67Zp0V_z3ZreLevMyMzDfPPgIOWNww4Blt_MQ8iiPRX4FcJ0DS7NI7JExywAiyBK2T8Y_yIgcef8OABxkckhGDCSkac7HZDZHt1rQBpe9bUNaY-NpqJa6t9j2nn7avqZr63RDTe261hpa46bbW087Rxu7RkeNda7uvPUn5KDSjcfTXT4mb48Pr5PnaDp7epncTyPDJfRRXKYyxkxowU1eGuQpsJhlRVHKTEApoJAxq0xaCc6YxiRjspSFSWKptUgM48fkcti7dN3HCn2vFtYbbBrdYrfySrCY8yROApgOoHGd9w4rtXR2od2XYqA2JtXWpNpoUgBqa1KJMHe-O7AqFlj-mRrUBeBiB2hvdFM53Rrrfzme54LLgN0NWBCLa4tOeRPMGiytQ9OrsrP_fPINkeiP5g</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Testa, Roberto</creator><creator>Franceschini, Roberto</creator><creator>Giannini, Edoardo</creator><creator>Cataldi, Angelo</creator><creator>Botta, Federica</creator><creator>Fasoli, Alberto</creator><creator>Tenerelli, Pasquale</creator><creator>Rolandi, Ermanno</creator><creator>Barreca, Tommaso</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000701</creationdate><title>Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis</title><author>Testa, Roberto ; Franceschini, Roberto ; Giannini, Edoardo ; Cataldi, Angelo ; Botta, Federica ; Fasoli, Alberto ; Tenerelli, Pasquale ; Rolandi, Ermanno ; Barreca, Tommaso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-2d592e67a73c8dce3501216bbd9670d70b921fc5f7311ae4619d9bc429aa74c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adipose Tissue - pathology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chronic viral hepatitis</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis B, Chronic - blood</topic><topic>Hepatitis B, Chronic - complications</topic><topic>Hepatitis B, Chronic - pathology</topic><topic>Hepatitis C, Chronic - blood</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Hepatitis C, Chronic - pathology</topic><topic>Humans</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Lidocaine - analogs & derivatives</topic><topic>Lidocaine - blood</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver Cirrhosis - virology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEGX30</topic><topic>Middle Aged</topic><topic>Organ Size</topic><topic>Other diseases. Semiology</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Testa, Roberto</creatorcontrib><creatorcontrib>Franceschini, Roberto</creatorcontrib><creatorcontrib>Giannini, Edoardo</creatorcontrib><creatorcontrib>Cataldi, Angelo</creatorcontrib><creatorcontrib>Botta, Federica</creatorcontrib><creatorcontrib>Fasoli, Alberto</creatorcontrib><creatorcontrib>Tenerelli, Pasquale</creatorcontrib><creatorcontrib>Rolandi, Ermanno</creatorcontrib><creatorcontrib>Barreca, Tommaso</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Testa, Roberto</au><au>Franceschini, Roberto</au><au>Giannini, Edoardo</au><au>Cataldi, Angelo</au><au>Botta, Federica</au><au>Fasoli, Alberto</au><au>Tenerelli, Pasquale</au><au>Rolandi, Ermanno</au><au>Barreca, Tommaso</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>33</volume><issue>1</issue><spage>33</spage><epage>37</epage><pages>33-37</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>Background/Aim: Serum levels of leptin, the adipocyte-derived hormone regulating food intake and energy expenditure in mammals, have been found to be increased in cirrhotic patients. The aim of the present study was to investigate leptin serum level in relation to anthropometric features and liver function in patients with viral chronic hepatitis or liver cirrhosis.
Methods: Serum leptin levels were determined by radioimmunoassay in 30 male and 10 female patients with chronic hepatitis, in 42 male and 10 female patients with liver cirrhosis, and in four respective control groups. Liver function was evaluated by the monoethylglycinexylidide formation test. Body mass index and body fat mass were estimated by weight, height and skinfold thickness measurements.
Results: Compared with controls, absolute serum leptin levels were significantly (
p<0.01) lower in chronic hepatitis patients and similar in cirrhotic patients. Leptin serum levels were significantly (
p<0.05) higher in cirrhotic than in chronic hepatitis patients. When expressed in relation to body fat mass, the above differences persisted; however, cirrhotic females showed significantly (
p<0;0.05) higher serum leptin values than controls. Serum leptin values correlated negatively (
p<0;0.01) with monoethylglycinexylidide serum values in all groups of patients.
Conclusions: In patients with chronic viral liver disease, serum leptin levels tend to increase as liver function worsens. This may reflect a decline in the ability to downregulate energy expenditure as an adaptation to anorexia and/or to defective substrate utilisation due to liver disease and may negatively influence body weight homeostasis in these patients.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>10905583</pmid><doi>10.1016/S0168-8278(00)80156-7</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of hepatology, 2000-07, Vol.33 (1), p.33-37 |
| issn | 0168-8278 1600-0641 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adipose Tissue - pathology Adult Biological and medical sciences Chronic viral hepatitis Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis B, Chronic - blood Hepatitis B, Chronic - complications Hepatitis B, Chronic - pathology Hepatitis C, Chronic - blood Hepatitis C, Chronic - complications Hepatitis C, Chronic - pathology Humans Leptin Leptin - blood Lidocaine - analogs & derivatives Lidocaine - blood Liver cirrhosis Liver Cirrhosis - blood Liver Cirrhosis - pathology Liver Cirrhosis - virology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences MEGX30 Middle Aged Organ Size Other diseases. Semiology Reference Values |
| title | Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis |
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